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MACS/Anti-FoxP3-PE, human and mouse (clone: 3G3)/130-098-119/

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Capacity:for30tests(1)

Overview

TheAnti-FoxP3antibodyspecificallyrecognizestheforkhead/winged-helixtranscriptionalregulatorFoxP3,alsoknownasforkheadboxP3,scurfin,andJM2.FoxP3isexpressedpredominantlyinregulatoryTcells(Tregs)andisamajorMarkerandfunctionalregulatorofTregcelldevelopmentandfunction.1,2MutationsintheFoxP3genearelinkedtotheautoimmunemanifestationsobservedintheScurfymouseandhumanswithimmunedysregulation,polyendocrinopathy,enteropathy,X-linked(IPEX)syndrome.3,4StudiesinmicehaveshownthatFoxP3-deficientanimalslackTregcells,whereasoverexpressionoftheFoxP3proteinleadstoprofoundimmunesuppression.

Technicaldata


AntigenFoxP3
Clone3G3
IsotypemouseIgG1κ
IsotypecontrolMouseIgG1–isotypecontrolantibodies
AlternativenamesofantigenAIID,DIETER,IPEX,JM2,PIDX,XPID
EntrezGeneID50943
Molecularmassofantigen[kDa]47
Cross-reactivityrhesusmonkey(Macacamulatta),cynomolgusmonkey(Macacafascicularis)
Distributionofantigen
Endotoxinlevel
ProductformatReagentsaresuppliedinbuffercontainingstABIlizerand0.05%sodiumazide.
FixationTheantibodyissuitedforstainingofformaldehyde-fixedcells.
StorageStoreprotectedfromlightat2–8°C.Donotfreeze.
AvailableconjugatesPE,APC
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