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MACS/Anti-CCL3 (MIP-1α)-FITC, human (clone: REA257)/130-103-693/188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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MACS/Anti-CCL3 (MIP-1α)-FITC, human (clone: REA257)/130-103-693/

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Capacity:for30tests(1)

Overview

CloneREA257recognizestheC-Cmotifchemokine3(CCL3)antigenalsoknownasMacrophageinflammatoryprotein1alpha(MIP-1α).CCL3isacytokinebelongingtothemembersoftheβ(CC)subfamilyofchemokines.ItisproducedbyTcells,Bcells,Langerhanscells,neutrophilsandmacrophages.CCL3isinvolvedinactivationandrecruitmentoflymphocytes,monocytes,andgranulocytesduringacuteinflammationandplaysaroleasachemoattractantofmonocytes,Bcells,eosinophilsandcytotoxicTcells.Ithasbeenidentifiedasastemcellinhibitoryfactorthatcaninhibittheproliferationofhematopoieticstemcellsinvitroaswellasinvivo.Moreover,CCL3hasbeenreportedtobeinvolvedinsusceptibilityofHIVinfectionanddiseaseprogressionofAIDS.ThefunctionalreceptorforCCL3hasbeenidentifiedasCCR1andCCR5.
Additionalinformation:CloneREA257displaysnegligIBLebindingtoFcreceptors.

Technicaldata


AntigenCCL3(MIP-1α)
CloneREA257
IsotyperecombinanthumanIgG1
IsotypecontrolREAControl(I)antibodies
AlternativenamesofantigenG0S19-1,LD78alpha,MIP-1-alpha,MIP1A,Scya3,TonsillarlymphocyteLD78alphaprotein
EntrezGeneID6348
Molecularmassofantigen[kDa]8
Cross-reactivity
DistributionofantigenBcells,Tcells,macrophages,dendriticcells
Endotoxinlevel
ProductformatReagentsaresuppliedinbuffercontainingstABIlizerand0.05%sodiumazide.
FixationTheantibodyissuitedforstainingofformaldehyde-fixedcells.
StorageStoreprotectedfromlightat2–8°C.Donotfreeze.
AvailableconjugatesFITC,PE,APC,PE-Vio770,APC-Vio770
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