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Medimabs/Anti-TC-PTP (C term) Mouse Monoclonal Antibody - Purified/MM-0019-P -- Purified T cell protein tyrosine phospha188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Medimabs/Anti-TC-PTP (C term) Mouse Monoclonal Antibody - Purified/MM-0019-P -- Purified T cell protein tyrosine phospha

  • ProductName
    Anti-TC-PTP(Cterm)MouseMonoclonalAntibody-Purified
  • Host
    Mouse
  • Clonality
    Monoclonal
  • ResearchArea(s)
    SignalTransduction,CellBIOLOGy,Immunology,Cancer
  • Immunogen
    C-terminalfragmentofTC-PTP
  • CloneID
    6F3
  • DataSHEET
    ViewDatasheet(PDF)
  • Isotype
    IgG1
  • Conjugation
    None
  • Reactivity
    TheantibodyrecognizestheC-terminalportionofTC-PTP.
  • Specificity
    mouseandrat
  • StorageBuffer
    PBS
  • Format
    100µg
  • Background
    Theproteintyrosinephosphatase(PTP)belongstoalargefamilyofenzymesinvolvedintheregulationofcellularsignalingandhomeostasis,eachpossessinga240aminoacidPTPdomain.TheT-cellproteintyrosinephosphatase(TC-PTP)ispredominantlyexpressedinthehematopoieticlineage.TC-PTPnullmicesufferseveredefectsinthehematopoieticcompartmentanddieat3-5weeksofagefromsevereanemia.TC-PTP-/-murineembryonicfibroblastshaveaslowprogressionthroughtheG1phaseofthecellcycleandhavecompromisedNF-κBactivation.JAK1and3havebeenidentifiedasphysiologicalsubstratesofTC-PTP.RecentgeneticstudieshaverevealedanassociationbetweenthePTPN2(TC-PTP)geneanddiseasesliketype1diabetesandCrohn"sdisease.
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