TwistDx – isothermal DNA and RNA amplification technology | Biotech 365

TwistDxisabiotechcompanyprovidingRecombinasePolymeraseAmplification(RPA),anewisothermalDNAorRNAamplificationanddetectiontechnology.

TwistDxisothermalDNAandRNAamplificationtechnology

TwistDxoffersanewisothermalDNA/RNAamplificationtechnology(RPA:RecombinasePolymeraseAmplification).RPAhasseveraltechnicaladvantagescomparedtoclassicaltechniques:speed(detectionin10-15minutes),sensitivity(singlemoleculedetection),simplicity(stablelyophilizedreagents),lowcost(littleornohardwarerequired),portable(isothermaltechnologywithbattery-poweredinstrumentordisposabletestformat)androbust(tosamplecontaminantsandtemperaturefluctuations).RPAoperatesatlow,constanttemperaturesanddoesnotrequireinitialmeltingofthesampleDNA.Furthermore,RPAhasbeenshowntofunctiondirectlyonsamplematerialthathasnotundergonea“traditional”nucleicacidpurificationprocedure.RPAcompatibletemplatehasbeensuccessfullypreparedfromnasalswabs,blood,culturemedia,orbysimplepathogenlysismethodsandwithoutfurtherisolationandpurificationofthenucleicacidmaterial.RecombinasePolymeraseAmplificationthereforeoffersaportable,isothermal alternativetoPCR.TwistDxmakesRPAaccessibletoresearchersintheformofTwistAmpkits.ThesesTwistAmpkitsareconfiguredwithoptionsforfluorescentandlateralflowdetectionmethods,electrophoresisandforDNAorRNAtargets.TwistAmpkitscontainallthereagentsresearchersneed(apartfromtarget-specificprobesandprimers)inordertodeveloptheirownrapid,highlysensitiveandspecificRPAassays.
TwistdxisabiotechcompanybasedinUKandManagementTeamiscomposedbyNiallArmes,OlafPiepenburg,DavidBrooksandHelenKent-Armes.TwistDxispursuingsignificantopportunitiestoapplyitsbreakthroughRPAtechnologytospecificnext-generationdiagnosticassays,includinginmedicaldiagnostics,industrialapplicationsandBiodefense.

MoreaboutTwistdx:www.twistdx.co.uk

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