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TwistDxiscelebratingthepublicationofthe200thpeer-reviewedpapertofeatureitsupandcomingRecombinasePolymeraseAmplification(RPA)technology,complementingexistingpublicationsinfieldsasdiverseaswatertesting,biodefense,foodspeciesverification,andclinicalandveterinarydiagnostics.ThisrepresentsasignificantmilestoneintheadoptionofitsRPAtechnologyinarelativelyshortperiodoftimecomparedtoothertechniques.EntitledArecombinasepolymeraseamplificationassaysforrapiddetectionofCrimean-Congohaemorrhagicfevervirusinfection(Bonneyetal2017.PLoSNeglTropDis11(10):e0006013),thepaperdescribestheuseofTwistDxstechnologytodeveloparapidandeasy-to-usemoleculardiagnostictestthatcanbeperformedusingalightweight,portabledetectiondevice.
ThisrepresentsasignificantmilestoneintheadoptionofitsRPAtechnologyinarelativelyshortperiodoftimecomparedtoothertechniques.
RPAisanisothermalDNA/RNAamplificationtechnologythateliminatestheneedforthermalcycling,offeringconsiderabletimesavingscomparedtoPCR,withoutcompromisingspecificity.Amplificationtypicallytakesbetweenthreeand10minutes,atlowincubationtemperatures,makingthetechnologyidealforreal-timedetectorsandfullyautomatedpoint-of-caredevicesdesignedforuseoutsidethelaboratory.DrNiallArmes,CEOofTwistDx,commented:Theever-growingnumberofpeer-reviewedpublicationsusingourtechnologydemonstratesthebenefitsofRPAasagenuinealternativetotraditionalPCRtechniques.Wearedelightedtoseethistechnologybeingappliedtoimportantmedicaladvances,andseethisasagreatleapforwardwithenormouspotentialformanyotherapplicationsinthefuture.