FGR|p59-Fyn|SLK|SrcKinasep59|SYN|FYNoncogenerelatedtoSRC,FGR,YES|FYNproto-oncogene
Description:CrystalStructureofFynkinasedomaincomplexedwithstaurosporine
Downloadallstructure-activitydataforthistargetasaCSVfile
EMDMilliporeKinaseProfilerTMscreen/ReactionBiologyKinaseHotspotSMscreen
Ascreenprofiling158kinaseinhibitors(CalbiochemProteinKinaseInhibitorLibraryIandII,cataloguenumbers539744and539745)fortheirinhibitoryactivityat1Mand10Magainst234humanrecombinantkinasesusingtheEMDMilliporeKinaseProfilerTMservice.
Ascreenprofilingtheinhibitoryactivityof178commerciallyavailablekinaseinhibitorsat0.5Magainstapanelof300recombinantproteinkinasesusingtheReactionBiologyCorporationKinaseHotspotSMplatform.
http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx
AnimalmodelsandcelllinestudiesindicateacriticalroleforFyninproximalT-cellantigenreceptor(TCR)signaltransduction[13].TCR-basedsignalsarerequiredatseveralstagesofT-celldevelopment.NotethatisthoughtthattherelatedSrctyrosinekinaseLckisthemajorcontributortoTCRsignaltransduction.
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Srcfamily:FYNproto-oncogene,Srcfamilytyrosinekinase.Lastmodifiedon16/07/2019.Accessedon18/05/2020.IUPHAR/BPSGuidetoPHARMACOLOGY,http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2026.
