Mychem/AminoPEG32\'deoxythymidine5\'hexylphosphate/A1019/1 µmole

产品介绍： 英文名称:3'-Azido-3'-deoxythymidine 5'-triphosphate triethyl ammonium saltCAS:92586-35-1纯度：95% 备注：GL102512 根据客户需要包装 产品介绍： 英文名称:3-Azido-3-deoxythymidine-5-triphosphateCAS:92586-35-1纯度：95% 包装信息：5mg 产品介绍： 英文名称:3'-Azido-3'-deoxythymidine-5'-triphosphate lithium salt - 100mM aqueous solutionCAS:92586-35-1 生物活性靶点体外研究中文名称:中文同义词:英文名称:3'-Azido-3'-deoxythymidine-5'-triphosphate英文同义词:Zidovudinetriphosphate;zidovudine 5'-triphosphate;3'-Azido-3'-deoxythymidine-5'-triphosphate lithium salt - 100mM aqueous solutionCAS号:92586-35-1分子式:C10H16N5O13P3·xLi分子量:0EINECS号:相关类别:Mol文件:92586-35-1.mol 3'-Azido-3'-deoxythymidine-5'-triphosphate 性质 3'-Azido-3'-deoxythymidine-5'-triphosphate 用途与合成方法生物活性AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) 是一种 Zidovudine (AZT) 的活性三磷酸酯代谢产物。AZT triphosphate 具有抗逆转录病毒的活性，并抑制 HIV 复制。AZT triphosphate 还可抑制 HBV 的 DNA 聚合酶。AZT triphosphate 可激活线粒体介导的凋亡 (apoptosis) 途径。靶点 DNA polymerase Reactive oxygen species (ROS) 体外研究 Treatment with 100 µM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in H9c2 cells. AZT triphosphate accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts.