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Productoverview

  • Name
    Z-DEVD-FMK
  • Shortdescription
    Irreversible,selectivecaspase3inhibitor
  • Biologicaldescription
    Irreversibleandselectivecaspase3inhibitor(IC50=0.13µM).Cellpermeable.ExhibitsnoactivityatcathespinBandcathespinL.Displaysneuroprotectivepropertiesandinhibitsapoptosis.
  • Biologicalaction
    Inhibitor
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • Chemicalname
    Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
  • MolecularWeight
    668.67
  • MolecularFormula
    C30H41FN4O12
  • CASNumber
    210344-95-9

StoringandUsingYourProduct

  • Storageinstructions
    -20°C
  • Solubilityoverview
    solubleinDMSO(13.37mg/ml)
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforZ-DEVD-FMK

  • ApoptosisofNG108-15cellsinducedbybuprenorphinehydrochlorideoccursviathecaspase-3pathway.

    KugawaFetal(2000)BiolPharmBull23(8):930-5.
    PubMedID:10963298

  • Involvementofcaspase-3-likeproteaseinthemechanismofcelldeathfollowingfocallyevokedlimbicseizures.

    HenshallDCetal(2000)JNeurochem74(3):1215-23.
    PubMedID:10693954

  • Identificationofapoptosis-associatedproteinsinahumanBurkittlymphomacellline.CleavageofheterogeneousnuclearribonucleoproteinA1bycaspase3.

    BrockstedtEetal(1998)JBiolChem273(43):28057-64.
    PubMedID:9774422

  • Developmentofnear-infraredfluorophore(NIRF)-labeledactivity-basedprobesforinvivoimagingoflegumain.

    LeeJetal(2010)ACSChemBiol5(2):233-43.
    PubMedID:20017516

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