Phentolamineisanonselectiveα-adrenergicreceptorantagonistthatexhibitsvasodilatoryandantihypertensiveactivities.Phentolamineisoccasionallyusedtotreaterectiledysfunction.Invivo,phentolamineinhibitsfructose-inducedincreasesinbloodpressureandactivatesATP-sensitiveK+channels,alteringCa2+signaling.
| CasNo. | 73-05-2 |
|---|---|
| Purity | ≥98% |
| Formula | C17H19N3O•HCl |
| FormulaWt. | 317.81 |
| ChemicalName | 3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methyl-phenyl)amino]phenolhydrochloride |
| IUPACName | 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol;hydrochloride |
| MeltingPoint | 239-240°C |
| Solubility | Solubleinwater(1g/50mL)andalcohol(1g/70mL).Slightlysolubleinchloroform.Practicallyinsolubleinacetoneandethylacetate. |
| Appearance | BrownCrystallinePowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | P2817MSDSPDF |
|---|---|
| InfoSheet | P2817InfoSheetPDF |
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AhnSW,KimSH,KimJH,etal.PhentolamineinhibitsthepacemakeractivityofmouseinterstitialcellsofCajalbyactivatingATP-sensitiveK+channels.ArchPharmRes.2010Mar;33(3):479-89.PMID:20361315.
DinsmoreWW,WyllieMG.Vasoactiveintestinalpolypeptide/phentolamineforintracavernosalinjectioninerectiledysfunction.BJUInt.2008Sep;102(8):933-7.PMID:18485029.