CeruleninisaninhibitoroffattyacidsynthasefoundinCephalosporium.Ceruleninexhibitsantibiotic,antifungal,andanticancerchemotherapeuticactivities.Incellularandanimalmodelsofcoloncancer,cerulenininducesapoptosisandcellulardeathanddecreasestumorgrowth.Ceruleninmayalsoinhibitinsulinsecretion.
| CasNo. | 17397-89-6 |
|---|---|
| Purity | ≥98% |
| Formula | C12H17NO3 |
| FormulaWt. | 223.27 |
| ChemicalName | (2R,3S)-3-[(4E,7E)-1-Oxo-4,7-nonadienyl]oxirane-carboxamide |
| IUPACName | (2R,3S)-3-[(4E,7E)-nona-4,7-dienoyl]oxirane-2-carboxamide |
| Synonym | Helicocerin |
| MeltingPoint | 93-94°C |
| Solubility | Solubleinethanol,acetone,orbenzene.Slightlysolubleinwater. |
| Appearance | Whitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | C1869MSDSPDF |
|---|---|
| InfoSheet | C1869InfoSheetPDF |
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PriceAC,ChoiKH,HeathRJ,etal.Inhibitionofbeta-ketoacyl-acylcarrierproteinsynthasesbythiolactomycinandcerulenin.Structureandmechanism.JBiolChem.2001Mar2;276(9):6551-9.PMID:11050088.
HuangP,ZhuS,LuS,etal.Cerulenininhibitsgrowthofhumancoloniccarcinomainnudemice.ZhonghuaBingLiXueZaZhi.2000Dec;29(6):435-8.PMID:11866947.