GLO1 Human

货号：	ENZ-398
保存条件：	-20°C
供应商：	上海沪震实业有限公司
保质期：	1年
英文名：	Glyoxalase-IHumanRecombinant
数量：	大量
规格：	10µg/50µg/1mg

GLO1Human

CATALOGUENUMBER

ENZ-398

SYNONYMS

GLYI,GLOD1,GLO1,Glyoxalase-1,Lactoylglutathionelyase,Methylglyoxalase,Aldoketomutase,Ketone-aldehydemutase,GlyoxalaseI,S-D-lactoylglutathionemethylglyoxallyase,GlxI.

INTRODUCTION

GLO1isinvolvedinthecatalysisandformationofS-lactoyl-glutathionefrommethylglyoxalcondensationandreducedglutatione.GLO1islinkedtoHLAandislocalizedto6p21.3-p21.1,betweenHLAandthecentromere.GLO1enzymeisubundantlyexpressedandpresentinnumeroustumorcelllines,inwhichitsconcentrationisoftenupregulatedubiquitisly.GLO1isamajorsusceptiblegeneforautisminanethnicChinesepopulationfromTaiwan.GLO1mightbeinvolvedinthepathophysiologyofmooddisorders.GLO1playsaroleinthepathophysiologyofmooddisorders.OverexpressionofGLO1isassociatedwithkidneytumor.

DESCRIPTION

Glyoxalase-IHumanRecombinantproducedinE.Coliisasingle,non-glycosylated,polypeptidechaincontaining184aminoacidsandhavingamolecularmassof20.7kDa. 
Glyoxalase-1ispurifiedbyproprietarychromatographictechniques.

SOURCE

EscherichiaColi.

PHYSICALAPPEARANCE

Sterilefilteredcolorlesssolution.

FORMULATION

Glyoxalase-1solutioncontaining20mMTris-HClpH-8,1mMDTTand10%glycerol.

STABILITY

Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime. 
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.

AMINOACIDSEQUENCE

MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQKCDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKMATLM.

PURITY

Greaterthan90.0%asdeterminedbySDS-PAGE.

USAGE

ProSpecsproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theymaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.