Doxorubicinisananthracyclinethatexhibitsanticancerchemotherapeuticandanti-parasitic,antimalarialactivities.DoxorubicinisaDNAintercalatorthatinhibitstopoisomeraseIIandisclinicallyusedtotreatvariouscancers;itispartoftheCHOPandABVDchemotherapyregimens.DoxorubicinalsopromoteshistoneH2AXevictionfromchromatin,limitingDNArepairmechanisms.Additionally,thiscompoundinhibitsgrowthofPlasmodium.
| CasNo. | 25316-40-9 |
|---|---|
| Purity | ≥98% |
| Formula | C27H29NO11•HCl |
| FormulaWt. | 579.99 |
| ChemicalName | (8S-cis)10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione |
| IUPACName | (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride |
| Synonym | Adriacin;Adriblastina;Adriamycin;Caelyx |
| MeltingPoint | 204-205°C(dec.) |
| Solubility | Solubleinwater,methanoloraqalcohols.SolubleinDMSOto10mg/mL.Insolubleinacetone,orchloroform. |
| Appearance | Orange-RedCrystalPowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | D5794MSDSPDF |
|---|---|
| InfoSheet | D5794InfoSheetPDF |
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