The effect of primary particle size on biodistribution of inhaled gold nanoagglomerates. PubMed.cn

Biomaterials2013Jul;34(22):5439-52.全文索取Theeffectofprimaryparticlesizeonbiodistributionofinhaledgoldnano-agglomerates.
BalasubramanianSK,PohKW,OngCN,KreylingWG,OngWY,YuLE.

Abstract
Airborneengineerednanoparticlesundergoagglomeration,andcarefuldistinctionmustbemadebetweenprimaryandagglomeratesizeofparticles,whenassessingtheirhealtheffects.Thisstudycomparestheeffectsonratsundergoing15-dayinhalationexposuretoairborneagglomeratesofgoldnanoparticles(AuNPs)ofsimilarsizedistributionandnumberconcentration(110(6)particles/cm(3)),buttwodifferentprimarydiametersof7nmor20nm.Inhalationofagglomeratescontaining7-nmAuNPsresultedinhighestdepositionbymassconcentrationinthelungs,followedbybrainregionsincludingtheolfactorybulb,hippocampus,striatum,frontalcortex,entorhinalcortex,septum,cerebellum;aorta,esophagus,andkidney.Eightorgans/tissuesespeciallythebrainretainedgreatermassconcentrationofAuafterinhalationexposuretoagglomeratesof7-nmthan20-nmAuNPs.MacrophagemediatedescalationfollowedbyfecalexcretionisthemajorpathwayofclearinginhaledAuNPsinthelungs.Microarrayanalysesofthehippocampusshowedmostlydownregulatedgenes,relatedtothecytoskeletonandneuriteoutgrowth.Together,resultsinthisstudyindicatedisintegrationofnanosizedagglomeratesafterinhalationandshowimpactofprimarysizeofparticlesonsubsequentbiodistribution.

PMID:23639527[Pubmed-MEDLINE]