D-Sphingosine is an endogenous component of sphingolipids that exhibits antibacterial activity against many gram positive and gram negative bacteria such as Escherichia, Staphylococcus, and Corynebacterium. D-Sphingosine also inhibits PKC.
| Cas No. | 123-78-4 |
|---|---|
| Purity | ≥98% |
| Formula | C18H37NO2 |
| Formula Wt. | 299.49 |
| Chemical Name | (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol |
| IUPAC Name | (E,2S,3R)-2-aminooctadec-4-ene-1,3-diol |
| Synonym | Sphingosine; 4-Sphingenine |
| Melting Point | 81-82°C |
| Solubility | Soluble in chloroform, DMSO. Insoluble in ethanol, acetone, water. |
| Appearance | Off- White Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | S6129 MSDS PDF |
|---|---|
| Info Sheet | S6129 Info Sheet PDF |
Fischer CL, Drake DR, Dawson DV, et al. Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria. Antimicrob Agents Chemother. 2012 Mar;56(3):1157-61. PMID: 22155833.
Huang Y, Zhang XY, Chen HL. Regulation of Phospholipase D Activity in Human Hepatocacinoma Cells by Protein Kinases and D-sphingosine. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 1999;31(5):572-576. PMID: 12114973.