Tacrolimusisacalcineurininhibitorthatexhibitsimmunosuppressive,anti-fibrotic,anti-inflammatory,andanti-allergicactivities.Clinically,tacrolimusisusedtotreatatopicdermatitisandconjunctivitis.Invivo,tacrolimusinhibitssynthesisoftypeIcollagenpolypeptidesandtheinteractionbetweenLARP6andFKBP3,suppressingthedevelopmentofalcohol-inducedliverfibrosis.InanimalmodelsofOVA-inducedallergy,tacrolimusdecreasesallergicsymptomsandlevelsofIgE,eosinophils,IL-5,andGATA-3.
| CasNo. | 104987-11-3 |
|---|---|
| Purity | ≥98% |
| Formula | C44H69NO12 |
| FormulaWt. | 804.02 |
| ChemicalName | 3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-5,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone |
| Synonym | FK-506;Fujimycin;Prograf;Protopic;CCRIS7124. |
| MeltingPoint | 126-130°C |
| Solubility | SolubleinDMSO(20mg/ml),ethanol(30mg/ml),acetone,ethylacetate,diethyletherorchloroform. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | T0008MSDSPDF |
|---|---|
| InfoSheet | T0008InfoSheetPDF |
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