Recombinant Human EGF-L7
Catalog Number:
100-61
Synonyms:
Epidermal growth factor-like protein 7, MEGF7, Multiple EGF-like domains, protein 7, NOTCH4-like protein, VE-statin, Zneu1
Description:
 
EGF-L7（Epidermal Growth Factor Like Protein 7, Multiple EGF Like Domains Protein 7, VE Statin）是一个多结构域蛋白，含有两个EGF样域和一个EMI域。EGF-L7几乎完全是在内皮细胞中表达，它的功能是促进血管系统的正常发育，尤其是管腔化。EGF-L7能够拮抗性结合Notch受体，从而抑制脐静脉内皮细胞(HUVEC)和神经干细胞中Notch信号通路。在诱发的缺氧及后续的的复氧（H/ R）研究模型中，EGF-L7可以抑制细胞间黏附分子-1(ICAM-1)的表达并增强对NF-κB活性的抑制作用。此外，EGF-L7可以趋化内皮细胞，并结合于细胞外基质。EGF-L7的过度表达可以在多种癌症中检测到，并通常与转移性增强和预后不良相关。重组人EGF-L7是一个分子量为28 kDa的蛋白，含有251个氨基酸残基。
AA Sequence:
MYRPGRRVCA VRAHGDPVSE SFVQRVYQPF LTTCDGHRAC STYRTIYRTA YRRSPGLAPA RPRYACCPGW KRTSGLPGAC GAAICQPPCR NGGSCVQPGR CRCPAGWRGD TCQSDVDECS ARRGGCPQRC VNTAGSYWCQ CWEGHSLSAD GTLCVPKGGP PRVAPNPTGV DSAMKEEVQR LQSRVDLLEE KLQLVLAPLH SLASQALEHG LPDPGSLLVH SFQQLGRIDS LSEQISFLEE QLGSCSCKKD S
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Data Not Available.
 
 
 
 
Research Interests:
Angiogenesis/ Cardiovascular
Cancer
Chemotaxis
Inflammation
Stem Cells & Differentiation
 
 
 
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.