重组人肿瘤坏死因子α Peprotech 30001A现货

重组人肿瘤坏死因子-αPeproTech300-01A现货
产品编号:

300-01A

别名:

TumorNecrosisFactor,TNFSF2,Cachectin,Differentiation-inducingfactor(DIF),Necrosin,Cytotoxin

描述:

TNF-αisapleiotropicpro-inflammatorycytokinesecretedbyvariouscells,includingADIpocytes,activatedmonocytes,macrophages,Bcells,Tcellsandfibroblasts.ItbelongstotheTNFfamilyofligands,andsignalsthroughtworeceptors,TNFR1andTNFR2.TNF-αiscytotoxictoawidevarietyoftumorcells,andisanessentialfactorinmediatingtheimmuneresponseagainstbacterialinfections.TNF-αalsoplaysaroleintheinductionofsepticshock,autoimmunediseases,rheumatoidarthritis,inflammation,anddiabetes.HumanandmurineTNF-αdemonstratesignificantcross-speciesreactivity.TNF-αexistsintwoforms;atypeIItransmembraneprotein,andamaturesolubleprotein.TheTNF-αtransmembraneproteinisproteoliticallycleavedtoyieldasoluble,BIOLOGicallyactive,17kDaTNF-α,whichformsanon-covalentlylinkedhomotrimerinsolution.RecombinantHumanTNF-αisasoluble157aminoacidprotein(17.4kDa)whichcorrespondstoC-terminalextracellulardomainofthefulllengthtransmembraneprotein.

氨基酸序列:

VRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

来源:

E.coli

纯度:

Greaterthan98%bySDS-PAGEgelandHPLCanalyses.

生物活性:

TheED₅₀asdeterminedbythecytolysisofmurineL929cellsinthepresenceofActinomycinDis≤0.05ng/ml,correspondingtoaspecificactivityof≥2x10⁷units/mg.

交叉反应:

Cow,Monkey,Mouse,Rat,Sheep,Human,Bacteria,Human+Rat,Pig,Dog,N/A,Human+Virus

研究领域:

	AIDS/HIV		血管生成/心血管
	细胞凋亡		癌症
	糖尿病/体重调节		免疫系统
	炎症		神经生物学
	干细胞及分化		TNF超家族
	过敏		移植

原产国:

USA

仅用于研究。不适用于诊断或治疗。

友情链接：其他

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重组人肿瘤坏死因子α Peprotech 30001A现货