Recombinant Human BMP-5
Catalog Number:
120-39
Synonyms:
none
Description:
TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs.  BMP-5 is expressed in the nervous system, lung and liver.  It is a known regulator for dendritic growth in sympathetic neurons.  BMP-5 is a 454 amino acid precursor protein that is cleaved to release the biologically active C-terminal mature protein.  Recombinant human BMP-5 is a 15.6 kDa homodimeric disulfide-linked protein consisting of two identical 138 amino acid chains.
AA Sequence:
AANKRKNQNR NKSSSHQDSS RMSSVGDYNT SEQKQACKKH ELYVSFRDLG WQDWIIAPEG YAAFYCDGEC SFPLNAHMNA TNHAIVQTLV HLMFPDHVPK PCCAPTKLNA ISVLYFDDSS NVILKKYRNM VVRSCGCH
Source:
CHO cells
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells.  The expected ED50 for this effect is 0.5-1.0 μg/ml.
 
 
 
 
Research Interests:
Bone, Skeletal, Cartilage
Neurobiology
TGF-β Superfamily
 
 
 
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.