Recombinant Human IL-36RA
Catalog Number:
200-36RA
Synonyms:
FIL1 delta, IL-1F5, IL-1HY1, IL-1L1, IL-1RP3, IL-1ra Homolog 1, IL-1, delta
Description:
IL-1由11个结构上相关的配体组成，包括最近重新命名的IL-36RA（IL-1F5），IL-36α（IL-1F6），IL-36β（IL-1F8）和IL-36γ（IL-1F9）。IL-36的配体和IL-1Rrp2受体（IL-1R6）之间相互作用，可诱导多种生物学活性，包括树突状细胞的成熟和活化等。IL-36RA可通过与IL-1Rrp2受体结合、阻止功能信号的启动，从而拮抗IL-36α，-β或-γ诱导的NF-κB信号通路。重组人IL-36RA由大肠杆菌表达的蛋白质，分子量为17 kDa，含有154个氨基酸残基。
AA Sequence:
VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAEKVIKGEE ISVVPNRALD ASLSPVILGV QGGSQCLSCG TEKGPILKLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTSPEADQPV RLTQIPEDPA WDAPITDFYF QQCD
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Measured by its ability to inhibit IL-36γ induced IL-6 production by human PBMCs.
 
 
 
 
Research Interests:
Cancer
Diabetes / Weight Regulation
Immune System
Inflammation
Neurobiology
Proliferation
Wound Healing
 
 
 
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.