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DescriptionRNA-Invivotransfer is a nanoscale polymer based reagent, successfully used to in vivo transfer siRNA, miRNA (mimic and inhibitor), guide RNA or long ncRNAs for research purposes such as gene functional studies or RNAi in vivo studies. This reagent interacts with nucleic acids and moves together into cells via endocytosis. In addition to efficiently transporting nucleic acids into the cells, the formula is also able to lead to the protection of the nucleic acids from degradation in vivo. RNA-Invivotransfer has been proven to be able to perform the maximum delivery of siRNA, miRNA (mimic and inhibitor), guide RNA or long ncRNAs into different organs in the body. No significant pro-inflammatory responses have been detected using this reagent.
RNA-Invivotransfer in vivo transfection reagent performs high transfection efficiency in vivo.
In vivo RNAi test: Systemic administration (i.v.) of RNA-Invivotransfer -in vivo Transfection Reagent conjugated with siRNA ( siRNA/mouse: 1mg/kg, 2mg/kg and 3mg/kg) targeting coagulation factor VII (FVII) gene mRNA or non-silencing control siRNA (3mg/kg) following our protocol. Liver was collected and total RNA isolated 48 hours after tail vein injection. Samples were analyzed by qRT-PCR for FVII mRNA expression levels. -Actin RNA levels were used to normalize the expression data. Data are means +/- SD (n=6).
No detectable inflammatory response.
Serum concentration of IL12/IL23 and IL6 following intravenous nucleic acid delivery using RNA-Invivotransfer or saline (negative control) 24h after injection respectively. The positive control is an IP injection of 50 g inactivated E.coli (LPS). 40ug siRNA were delivered with or without RNA-Invivotransfer .
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厌氧产气袋[供应商：北京缘生化科技有限公司]