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The Brightest Light …

NanoLight^® Technologies is a division of Prolume Ltd., formed by Prolume’s founder Dr. Bruce Bryan and a group of excellent co-founders from Prolume^® Ltd. namely Byron Ballou PhD; Gene Finely MD; Chris Szent-Gyorgyi PhD; Randall Murphy PhD and Miroslav Trampota.

Nanolight^® Technology is a biotechnology company developing broad applications of natural, light-emitting marine proteins, or marine bioluminescence. The NanoLight division is focused on becoming the leader in high-value reagent & reporter systems for new product development in the pharmaceutical, agrichemical, and research products industries.

Valuable life science uses for NanoLight^®’s technology include high-throughput drug discovery, functional genomics, tumor imaging, replacement of radioisotopes, and molecular diagnostics. One particularly exciting application is the ability to use NanoLight^®’s reporter systems to “illuminate” gene and molecular function within living cells, allowing pharmaceutical companies a revolutionary method to study drug activity. A second opportunity is to broadly supply researchers who are increasingly moving away from radioactive reagents toward light-based reporter systems and instruments. NanoLight^® Technologies is poised to capitalize on both of these accelerating market trends.

NanoLight’s competitive advantage

Our advantage is based on three crucial proprietary positions:

Access to the novel bioluminescent and fluorescent protein molecules.
World’s lowest-cost production technology for coelenterazine (NanoFuel™), necessary for light emission.
World’s largest collection of expression libraries from marine bioluminescent organisms.These proprietary technologies, which NanoLight has already developed or protected by patent filings & trade secrets, permit the company to grow into the dominant supplier of proprietary bioluminescent reagents and reporter systems to the life science markets. NanoLight^® can immediately provide partners access to:
- Novel GFP genes isolated from Ptilosarcus gurneyi and Renilla Mulleri with distinctive properties including a novel chromophore sequence that differs in 3 of 6 residues from the Aequorea GFP.
- Novel marine luciferases cloned from Renilla Mulleri, Pleuromama sp., and Gaussia sp., the latter appears to be brighter than existing Renilla or Firefly systems in mammalian cells.
- Pending patents on the novel use of bioluminescent proteins on silicon chips for inexpensive high throughput screening and diagnostic applications.
- cDNA libraries from over forty (40) different luminescent organisms for further gene discovery patenting, and licensing.
- Proprietary functional screening methods to identify new bioluminescent genes.
This enormous genetic resource represents an outstanding opportunity for leading life sciences companies racing to establish advanced high-throughput screening and diagnostic systems.

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The Brightest Light …

NanoLight’s competitive advantage