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Nanolight/hCoelenterazine (in vivo)/301110 (20x 500ug)/10 mgs188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Nanolight/hCoelenterazine (in vivo)/301110 (20x 500ug)/10 mgs
NEW!h-Coelenterazinewasformulatedtobewater-solubleandsafefor invivo imagingapplicationswithRenillaLuciferase.
 
CoelenterazinecompoundsareoftendissolvedinPropyleneglycol(PG)incombinationwithotheralcoholsfor invivo imagingstudies.LargeintravenousdosesofPGgivenoverashortperiodoftimecanbetoxic,including hyperosmolality,increasedaniongapmetabolicacidosis(duetolacticacidosis),acutekidneyinjury,andsepsis-likesyndrome.

Thiscanbeavoidedusingwater-solubleh-Coelenterazine.Itisformulatedtobeisosmoticandeasilysecretedbythekidneys.Thussaveforrepeatedi.v.injections.Water-solubleh-Coelenterazinecanbeinjecteduptoa500µg/100µlconcentration,achievingveryhighCoelenterazinelevelswithinthebodyandleADIngtohighluciferasesignals.
 
h-CoelenterazineisoneofthepreferredsubstratesforRenillaLuciferase.
IfyouuseGaussiaLuciferaseinyourassaypleaseuseCat.#3031.
 
content:
h-Coelenterazine+non-toxicadditivesforwater-solublity
packagingsize:
500 µgh-CTZ/vialinafreeze-driedform
storage:


vacuumsealedvialscanbestoredat:
-80°Cforlong-termstorage
-20°Cforshort-termstorage Storedryanddark!
application:
justaddsterilewater,vortexanduseupto500µgCTZinasingleinjection 
applicationexample:





h-CoelenterazineisoftenusedincombinationwithRenillaLuciferases
AdetaileddescribtionofthisnewwatersolubleCoelenterazine(incombinationwithGaussiaLuciferase)canbefoundin:

  AWater-SolubleCoelenterazineforSensitiveInVivoImagingofCoelenterate
  Luciferases. DanielleMorse and BakhosATannous
  MolecularTherapy 20,692-693(April2012)| doi:10.1038/mt.2012.38

Manualforh-CTZ-SOL(invivo)    MSDS

Advantagesofwater-solubleCoelenterazine:

  • non-toxic,iso-osmotic,Propylene-Glycolfree,Alcoholfree
  • longshelf-life,sealedundervacuum
  • dissolvesfastinsterilewater
  • lowviscosity-idealforinjections
  • consistentqualityduetosmallaliquotsizes(10mgswillbeshippedas20x500ug)

 Shipping:viaFedExorUPSatRT,overnightor2nddelivery.Storeat-80°C. 


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