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Adipogen/Netrin1 (human) (rec.)/AG40B00403010/3 x 10 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Adipogen/Netrin1 (human) (rec.)/AG40B00403010/3 x 10 µg

MoreInformation
ProductDetails
SynonymsNTN1
ProductTypeProtein
Properties
Source/HostHEK293cells
SequenceHumannetrin-1(aa25-604)isfusedattheC-terminustoaFLAG®-tag.
CrossreactivityHuman
Mouse
Rat
SpecificityBindstohuman,mouseandratUNC5B.
BIOLOGicalActivityInducespluripotentstemcell(iPS)formationandimprovesreprogrammingefficiencyofhumanandmousesomaticcellsbyinhibitingapoptosismediatedbythereceptorsDCCorUNC5B(at150ng/ml).Inducesaxonoutgrowth.
MW~80kDa(SDS-PAGE)
Purity≥95%(SDS-PAGE)
EndotoxinContent<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">
Concentration10µgvial:0.1mg/mlafterreconstitution.
100µgvial:1mg/mlafterreconstitution.
ReconstitutionReconstitutewith100μlsteriledistilledwater.
FormulationLyophilized.ContainsPBSplusproteinstABIlizer.NoBSAincluded.Theproteinstabilizershowsnointerferencewithproteinactivity.
OtherProductDataUniProtlinkO95631:Netrin-1(human)
ShippingandHandling
ShippingBLUEICE
ShortTermStorage+4°C
LongTermStorage-20°C
HandlingAdviceAfterreconstitution,preparealiquotsandstoreat-20°C.
Avoidfreeze/thawcycles.
PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions.
Use/StabilityStableforatleast6monthsafterreceiptwhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
Netrin-1controlsguidanceofCNScommissuralaxonsandperipheralmotoraxons.ItsassociationwitheitherDCCorsomeUNC5receptorswillleadtoaxonattractionorrepulsion,respectively.Italsoserveasasurvivalfactorviaitsassociationwithitsreceptorswhichpreventtheinitiationofapoptosis.Netrin-1isalsoInvolvedintumOrigenesisbyregulatingapoptosis.Netrin-1promotesatherosclerosisbyretainingmacrophagesinthearterywall.Netrin-1alsogovernsinducedpluripotentstemcell(iPS)formationandimprovesreprogrammingefficiencyofhumanandmousesomaticcellsbylimitingapoptosismediatedbyNetrin-1receptorsDCCorUNC5b.
ProductReferences
  1. Netrin-1regulatessomaticcellreprogrammingandpluripotencymaintenance:D.Ozmadenci,etal.;Nat.Commun.6,ID7398(2015)
  2. Targetingnetrin‐1/DCCinteractionindiffuselargeB‐cellandmantlecelllymphomas:L.Broutier,etal.;EMBOMol.Med.8,96(2016)
  3. InhibitionofDNAmethylationpromotesbreasttumorsensitivitytonetrin‐1interference:M.Grandin,etal.;EMBOMol.Med.8,863(2016)

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