Description
IsothiocyanatesarecompoundstypicallyfoundinplantsoftheBrassicaceaefamily,includingbroccoli,cabbage,andradish.Isothiocyanatesarebestknownfortheirantioxidative,anticancerchemotherapeutic,chemopreventive,anti-angiogenic,andantibioticproperties.Invitro,phenhexylisothiocyanate(PHITC)increasescaspase3activityandcleavageofpoly(ADP)-ribosepolymerase(PARP),inducingcaspase-mediatedapoptosisincellularmodels.ThiscompounddecreasesoxidationofcarcinogenNNKandincreasesactivityofNADPH:quinoneoxidoreductaseandglutathioneS-transferaseinvitroandinvivo.PHITCinhibitshistonedeacetylase(HDAC)activity,IL-6receptorproduction,andVEGFexpression;italsoinducesmitochondrialmembranedepolarizationandapoptosisinmyelomacells.Inleukemiacells,PHITCinhibitsexpressionofcyclinandincreasesexpressionofcyclindependentkinase(CDK)inhibitors,inducingapoptosisandinhibitinggrowthofxenograftsofthesecellsinanimals.