Adipogen/Prostaglandin E<sub>2</sub>/AGCL10001M001/1 mg

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ProductDetails
Synonyms	PGE2;Dinoprostone;9-Oxo-11α,15S-dihydroxy-prosta-5Z,13E-dien-1-oicacid;ProstinE2;Prepidil;NSC165560;11α,15α-Dihydroxy-9-oxo-5-cis,13-trans-prostADIenoicacid
ProductType	Chemical
Properties
Formula	C₂₀H₃₂O₅
MW	352.5
MerckIndex	14:7877
CAS	363-24-6
RTECS	UK8000000
Source/HostChemicals	Synthetic(originallyisolatedfromsheepprostate).
PurityChemicals	≥98%
Appearance	Whitesolid.
Solubility	Solubleinethanol(50mg/ml),DMSO(50mg/ml)orDMF(100mg/ml).SparinglysolubleinPBS,pH7.2(5mg/ml).
Crossreactivity	Multi-species
OtherProductData	DonotaddPGE₂tobasicsolutionwithpH>7.4.
InChiKey	XEYBRNLFEZDVAW-ARSRFYASSA-N
ShippingandHandling
Shipping	BLUEICE
ShortTermStorage	+4°C
LongTermStorage	-20°C
HandlingAdvice	Keepcoolanddry. Protectfromlight.
Use/StABIlity	Stableforatleast2yearsafterreceiptwhenstoredat-20°C.
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MSDS	DownloadPDF
ProductSpecificationSheet
Datasheet	DownloadPDF

Oneofthemosttypicallipidmediatorsproducedfromarachidonicacid(AA)bycyclooxygenase(COX)astherate-limitingenzymeandactsonfourkindsofreceptorsubtypes(EP1,EP2,EP3andEP4)withhighbindingaffinity(Kdvaluesrangebetween~1-10nM).
Regulatorofnumerousphysiologicalfunctionsrangingfromreproductiontoneuronal,metabolicandimmunefunctions.
Impliedintheregulationofbodytemperatureandsleep-wakeactivity.Regulatingfactorforboneformationandbonehealing.Potentvasodilator.Influencessmoothmusclerelaxation,fertilityandgastricmucosalintegrity(firstlineofdefenseoftheintestinalimmunesystem).
Actsasapro-inflammatorymediator,butalsoexertsanti-inflammatoryresponses.Aspro-inflammatorymediator,PGE2contributestotheregulationofthecytokineexpressionprofileofDCsandhasbeenreportedtobiasTcelldifferentiationtowardsaThelper(Th)1orTh2response.Exertsanti-inflammatoryactionsoninnateimmunecellslikeneutrophils,monocytesandNKcells.
ImplicatedinvarioustumOrigenicprocesses.FacilitatestumorprogressionthroughstimulationofangiogenesisviaEP2,mediatescellinvasionandmetastasisformationviaEP4andpromotescellsurvivalbyinhibitingapoptosisvianumeroussignalingpathways.Tumorcell-producedPGE2hasbeenimplicatedinstrategiesoftumorsforevasionofimmunesurveillance.FurThermore,itcanenhancetheinhibitoryfunctionofhumanregulatoryTcells.
Regulatesvertebratehematopoieticstemcell(HSC)homeostasis.
InhibitsNLRP3byactingthroughreceptorEP4activationthatincreasescAMP.cAMPactivatesPKAthatphosphorylatesNLRP3atserine295.PKAphosphorylationofNLRP3inhibitstheNLRP3ATPaseactivity,whichisrequiredforassemblyofNLRP3-ASCcomplexes.

ProductReferences

ProstaglandinE2atnewglance:novelinsightsinfunctionaldiversityoffertherapeuticchances:D.F.Legler,etal.;Int.J.Biochem.CellBiol.42,198(2010)(Review)
ProstaglandinE2,animmunoactivator:D.Sakata,etal.;J.Pharmacol.Sci.112,1(2010)(Review)
NewlyemergingrolesforprostaglandinE2regulationofhematopoiesisandhematopoieticstemcellengraftment:E.M.Durand,etal.;Curr.Opin.Hematol.17,308(2010)(Review)
Prostanoidsignaling:dualroleforprostaglandinE2inneurotoxicity:D.Milatovic,etal.;Neurotoxicol.32,312(2011)(Review)
ProstaglandinE2EPreceptorsastherapeutictargetsinbreastcancer:J.Reader,etal.;CancerMetastasisRev.30,449(2011)(Review)
ProstaglandinE2andTcells:friendsorfoes?V.Sreeramkumar,etal.;Immunol.CellBiol.90,579(2012)(Review)
RegulationofimmuneresponsesbyprostaglandinE2:P.Kalinski;J.Immunol.188,21(2012)(Review)
PolarizationoftheinnateimmuneresponsebyprostaglandinE2:apuzzleofreceptorsandsignals:M.Rodriguez,etal.;Mol.Pharmacol.85,187(2014)(Review)
ProstaglandinE2-inducedinflammation:RelevanceofprostaglandinEreceptors:K.Kawahara,etal.;Biochim.BiophysActa.1851,414(2015)(Review)
ProstaglandinE2andtheEPreceptorsinmalignancy:possIBLetherapeutictargets?G.OCallaghan&A.Houston;Br.J.Pharmacol.172,5239(2015)(Review)
ProstaglandinE2InhibitsNLRP3InflammasomeActivationthroughEP4ReceptorandIntracellularCyclicAMPinHumanMacrophages:M.Sokolowska,etal.;J.Immunol.194,5472(2015)
NLRP3inflammasomeinhibitionisdisruptedinagroupofauto-inflammatorydiseaseCAPSmutations:L.Mortimer,etal.;Nat.Immunol.(Epubaheadofprint)(2016)

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Adipogen/Prostaglandin E<sub>2</sub>/AGCL10001M001/1 mg