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Adipogen/PP1/AGCR13562M001/1 mg
MoreInformation
ProductDetails
Synonyms4-Amino-5-(methylphenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine
ProductTypeChemical
Properties
FormulaC16H19N5
MW281.4
CAS172889-26-8
PurityChemicals≥98%(HPLC)
AppearanceWhitesolid.
SolubilitySolubleinDMSO.Slightlysolubleinethanol.
InChiKeyZVPDNRVYHLRXLX-UHFFFAOYSA-N
ShippingandHandling
ShippingAMBIENT
ShortTermStorage+4°C
LongTermStorage-20°C
Use/StabilityStableforatleast2yearsafterreceiptwhenstoredat-20°C.
Workingaliquotsarestableforupto3monthswhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
  • HighlypotentandselectiveScrfamilytyrosinekinaseinhibitor[1,2,6,9].
  • Showsanti-RascancerpotentialbyblockingRas-inducedactivationofPAK1[4].
  • Antitumorcompound[3,4,5,7]. 
  • RIP2inhibitor[9].
  • BlocksTGF-β-mediatedcellularresponses[8,10].
ProductReferences
  1. Discoveryofanovel,potent,andSrcfamily-selectivetyrosinekinaseinhibitor.StudyofLck-andFynT-dependentTcellactivation:J.H.Hanke,etal.;J.Biol.Chem.271,695(1996)
  2. Srcfamily-selectivetyrosinekinaseinhibitor,PP1,inhibitsbothFcepsilonRI-andThy-1-mediatedactivationofratbasophilicleukemiacells:M.Amoui,etal.;Eur.J.Immunol.27,1881(1997) 
  3. LckassociateswithandisactivatedbyKitinasmallcelllungcancercellline:inhibitionofSCF-mediatedgrowthbytheSrcfamilykinaseinhibitorPP1:G.W.Krystal,etal.;CancerRes.58,4660(1998)
  4. Ananti-RascancerpotentialofPP1,aninhibitorspecificforSrcfamilykinases:invitroandinvivostudies:H.He,etal.;CancerJ.6,243(2000)
  5. ThekinaseinhibitorPP1blockstumorigenesisinducedbyREToncogenes:F.Carlomagno,etal.;CancerRes.62,1077(2002)
  6. Thespecificitiesofproteinkinaseinhibitors:anupdate:J.Bain,etal.;Biochem.J.371,199(2003)
  7. TheSrc-selectivekinaseinhibitorPP1alsoinhibitsKitandBcr-Abltyrosinekinases:L.Tatton,etal.;J.Biol.Chem.278,4847(2003)
  8. Srcactivationisnotnecessaryfortransforminggrowthfactor(TGF)-beta-mediatedepithelialtomesenchymaltransitions(EMT)inmammaryepithelialcells.PP1directlyinhibitsTGF-betareceptorsIandII:M.Maeda,etal.;J.Biol.Chem.281,59(2006)
  9. Theselectivityofproteinkinaseinhibitors:afurtherupdate:J.Bain,etal.;Biochem.J.408,297(2007)
  10. TheSrcfamilykinaseinhibitorsPP2andPP1blockTGF-beta1-mediatedcellularresponsesbydirectanddifferentialinhibitionoftypeIandtypeIITGF-betareceptors:H.Ungefroren,etal.;Curr.CancerDrugTargets11,524(2011)

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