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Productoverview

  • Name
    Zebularine
  • Shortdescription
    DNAmethyltransferaseinhibitor.InducescardiomyocytedifferentiationinMSCs.
  • Biologicaldescription
    DNAmethyltransferaseinhibitor.Stabilisesp53incolorectalcancercellsandcausesp53-dependentERstressandautophagy.Alsoinhibitscytidinedeaminaseandinfluencesembryonicstemcelldifferentiation.Showsanti-proliferativeandanti-canceractions.
  • Alternativenames
    1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one;2-Pyrimidone-1-β-D-riboside;NSC309132;Zeb
  • Biologicalaction
    Inhibitor
  • Purity
    >99%
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • Chemicalname
    1-β-D-Ribofuranosyl-2(1H)-pyrimidinone
  • MolecularWeight
    228.2
  • Chemicalstructure
    Zebularine [654065]
  • MolecularFormula
    C9H12N2O5
  • CASNumber
    654065

StoringandUsingYourProduct

  • Storageinstructions
    roomtemperature(desiccate)
  • Solubilityoverview
    solubleinwater(100mM)orDMSO(100mM)
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforZebularine

  • Zebularineinhibitstumorigenesisandstemnessofcolorectalcancerviap53-dependentendoplasmicreticulumstress.

    YangPMetal(2013)SciRep3:3219
    PubMedID:24225777

  • ZebularineregulatesearlystagesofmESCdifferentiation:effectoncardiaccommitment.

    HorrilloAetal(2013)CellDeathDis4:e570.
    PubMedID:23559004

  • Potentinhibitorsforthedeaminationofcytosinearabinosideand5-aza-2-deoxycytidinebyhumancytidinedeaminase.

    Lalibertã?Jetal(1992)CancerChemotherPharmacol30(1):7-11.
    PubMedID:1375134

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