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Adipogen/Ganglioside GQ1b . tetrasodium salt/AGCN29007C500/500 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Adipogen/Ganglioside GQ1b . tetrasodium salt/AGCN29007C500/500 µg

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ProductDetails
SynonymsGQ1b.4Na;TetrasialogangliosideGQ1b.4Na
ProductTypeChemical
Properties
FormulaC106H178N6O55.4Na
MW2416.6.92.0(calculatedonsphingosine
C18:1andstearicacid)
SequenceStructure:IV3Neu5Ac2II3NeuAc2GgOse4Cer;α-Neu5Ac-(2-8)-α-Neu5Ac-(2-3)-β-Gal-(1-3)-β-GalNAc-(1-4)-[α-Neu5Ac-(2-8)-α-Neu5Ac-(2-3)-]β-Gal-(1-4)-β-Glc-(1-1)-Cer;Cer:SphingosineC18:1-C20:1,~1:1byvol.;stearicacidover90%
CAS68652-37-9
Source/HostChemicalsIsolatedfrombovinebrain.
PurityChemicals≥98%(TLC)
SolubilitySolubleinwater(micellaraggregates)orchloroform:methanol(2:1).
FormulationLyophilized.
EndotoxinContentNotdetectable.
IdentityDeterminedby1H-NMR,MSandHPTLC.
InChiKeyQISNAVHLOKDTLS-UTKQHEHRSA-J
ShippingandHandling
ShippingAMBIENT
ShortTermStorage+4°C
LongTermStorage-20°C
HandlingAdviceHygroscopic.
Protectfrommoisture.
Use/StabilityStableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
Gangliosidesareacidicglycosphingolipidsthatformlipidraftsintheouterleafletofthecellplasmamembrane,especiallyinneuronalcellsinthecentralnervoussystem.Theyparticipateincellularproliferation,differentiation,adhesion,signaltransduction,cell-to-cellinteractions,tumorigenesisandmetastasis.Theaccumulationofgangliosideshasbeenlinkedtoseveraldiseases.GangliosideGQ1bspecificallypromotesneuraldifferentiationofhumanneuroblastomacells.Anti-GQ1bantibodiesarepresentinserumfromMiller-Fishersyndromepatients.
ProductReferences
  1. Roleofmembranegangliosidesinthebindingandactionofbacterialtoxins:P.H.Fishman;J.Membr.Biol.69,85(1982)
  2. Anovelglycosignalingsystem:GQ1b-dependentneuritogenesisofhumanneuroblastomacellline,GOTO,iscloselyassociatedwithGQ1b-dependentecto-typeproteinphosphorylation.S.Tsuji,etal.;Neurochem.21,549(1992)
  3. Dynamicandstructuralpropertiesofsphingolipidsasdrivingforcetotheformationofmembranedomains:S.Sonnino,etal.;Chem.Rev.106,2111(2006)
  4. Fishersyndrome:clinicalfeatures,immunopathogenesisandmanagement.M.Mori,etal.;ExpertRev.Neurother.12,39(2012)

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