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| AlternativeName: | TGFR-3,TransforminggrowthfactorβreceptorIII,Betaglycan |
| Clone: | Jack-1 |
| Host: | Mouse |
| Isotype: | IgG2b |
| Immunogen: | RecombinanthumanTGF-βRIIIcytoplasmicdomain(aa809-850). |
| UniProtID: | Q03167 |
| Source: | Purifiedfromconcentratedhybridomatissueculturesupernatant. |
| Speciesreactivity: | Human |
| Applications: | IP,WB |
| RecommendedDilutions/Conditions: | Immunoprecipitation(1:200) Suggesteddilutions/conditionsmaynotbeavailableforallapplications. Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| PurityDetail: | ProteinG-affinitypurified. |
| Formulation: | Liquid.InPBScontaining0.02%sodiumazide. |
| Use/Stability: | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Handling: | Avoidfreeze/thawcycles.Afteropening,preparealiquotsandstoreat-20°C. |
| Shipping: | ShippedonBlueIce |
| ShortTermStorage: | +4°C |
| LongTermStorage: | -20°C |
| ScientificBackground: | TGF-βreceptorIII(TGF-βRIII;betaglycan)isanubiquitouslyexpressedtransmembraneproteoglycanTGF-βco-receptorthatregulatesTGF-βsignallingbyincreasingthebindingofTGF-βtothesubunitIIorTGF-βreceptor.(Note:TheTGF-βreceptorIIIisaco-receptorofTGF-βreceptor,composedofsubunitIandII;TGF-βreceptorIIIincreasesthebindingofTGF-βtothesubunitII.Inthiswayitcanregulatethesignaling.)TGF-βreceptorIIIexpressionislostinmanyhumanbreastandprostatecancersandcorrelateswiththeresistancetothetumorsuppressoreffectsofTGF-β.TheoverexpressionofTGF-βreceptorIIIinbreastcancercellssuppressestheirtumorigenicityinananimalmodel. |