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| AlternativeName: | Core-bindingfactorα3subunit,AML-2,Acutemyeloidleukemia2protein,CBF-α3,Runt-relatedtranscriptionfactor3 |
| Clone: | R3-6E9 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | RecombinanthumanRUNX3(runt-relatedtranscriptionfactor3)(aa191-300). |
| UniProtID: | Q13761 |
| Speciesreactivity: | Human |
| Crossreactivity: | Weaklycross-reactswithmouseRUNX3. |
| Applications: | IHC(PS),IP,WB |
| RecommendedDilutions/Conditions: | Immunohistochemistry(paraffinsections,2µg/ml) WesternBlot(0.2µg/ml) Suggesteddilutions/conditionsmaynotbeavailableforallapplications. Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| Formulation: | Liquid.InPBScontaining10%glyceroland0.02%sodiumazide. |
| Handling: | Avoidfreeze/thawcycles.Afteropening,preparealiquotsandstoreat-20°C. |
| Shipping: | ShippedonBlueIce |
| ShortTermStorage: | +4°C |
| LongTermStorage: | -20°C |
| ScientificBackground: | RUNX(Runt-relatedtranscriptionfactor)familymembersplayimportantrolesinnormaldevelopmentalprocessesandcarcinogenesis.OfthethreeknownRUNXfamilymembers,theubiquitouslyexpressedRUNX3isinvolvedinneurogenesis,Tcelldifferentiation,tumorigenesisandisacomponentoftheTGF-βinducedtumorsuppressorpathway.Ingastriccancercells,RUNX3inducescellcyclearrestandapoptosisthroughupregulationofBim,aproapoptoticBH3-onlyprotein.Inaddition,RUNX3isfrequentlyinactivatedingastriccancercells. |