Innovative Research/Mouse Neuropilin2 ELISA Kit/IRKTAH5422/1 Ea

ProductDescription

MouseNeuropilin-2ELISAKit-1Kit(96Wells)

OurMouseNeuropilin-2ELISAKitisasandwichELISAintendedforthequantitativedeterminationofmouseNeuropilin-2incellculturesupernates,celllysatesandtissuehomogenates.

NRP2(Neuropilin-2),alsocalledNpn2orVEGF165R2,encodesamemberoftheneuropilinfamilyofreceptorproteins.ThesolubleNRP2wassecretedasa62.5-kDproteinfollowingtransfectioninChinesehamsterovarycells.TheNRP2geneismappedto2q33.3.TheNRP2genecontains17exonsandspansabout112kb.Thisproteinmayplayaroleincardiovasculardevelopment,axonguidance,andtumorigenesis.MicewithnullmutationsingenesencodingSema3F,anditsholoreceptorcomponentsNpn2andplexinA3(PLEXA3),exhibitincreaseddentategyrusgranulecellandcorticallayerVpyramidalneuronspinenumberandsize,andalsoaberrantspinedistribution.Moreover,Sema3Fpromoteslossofspinesandexcitatorysynapsesindissociatedneuronsinvitro,andinNRP2-nullbrainslicescorticallayerVanddentategyrusgranulecellsexhibitincreasedminiatureexcitatorypostsynapticcurrentfrequency.ThesedisparateeffectsofsecretedsemaphorinsarereflectedintherestricteddendriticlocalizationofNRP2toapicaldendritesandofNpn1toalldendritesofcorticalpyramidalneurons.

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