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LKT/TANSHINONE I/T0153/25 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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LKT/TANSHINONE I/T0153/25 mg

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  • ProductInfo
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  • References

Description

TanshinoneIisaditerpenefoundinSalviathatexhibitsneuroprotective,anti-inflammatory,antioxidative,anti-angiogenic,anticancerchemotherapeutic,andchemopreventiveactivities.TanshinoneIupregulatesexpressionofIL-4andIL-13,protectingagainstcerebralischemia/reperfusion-inducedinjuryinvivo.TanshinoneIalsodecreasesperoxynitrite-inducedDNAdamageandradicalformation.Additionally,tanshinoneIinhibitsexpressionofVEGF,cyclinA,cyclinB,andAurAinvariousmodelsoflungcancer,inhibitingcellularandtumorgrowth.

ProductInfo

CasNo.

568-73-0

Purity

≥95%

Formula

C18H12O3

FormulaWt.

276.29

ChemicalName

1,6-Dimethylphenanthro(1,2-b)furan-10,11-dione

IUPACName

1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dione

Synonym

TanshinoneA

MeltingPoint

233-234°C

Solubility

SolubleinDMSO.

Appearance

Darkpurplecrystal

ShippingandStorage

StoreTemp

4°C

ShipTemp

Ambient

Downloads

MSDS

T0153MSDSPDF

InfoSheet

T0153InfoSheetPDF

References

ParkJH,ParkOK,ChoJH,etal.Anti-inflammatoryEffectofTanshinoneIinNeuroprotectionAgainstCerebralIschemia-ReperfusionInjuryintheGerbilHippocampus.NeurochemRes.2014Apr24.[Epubaheadofprint].PMID:24760430.

ZhouS,ChenW,SuH,etal.ProtectivepropertiesoftanshinoneIagainstoxidativeDNAdamageandcytotoxicity.FoodChemToxicol.2013Dec;62:407-12.PMID:24021569.

TungYT,ChenHL,LeeCY,etal.ActiveComponentofDanshen(SalviamiltiorrhizaBunge),TanshinoneI,AttenuatesLungTumorigenesisviaInhibitionsofVEGF,CyclinA,andCyclinBExpressions.EvidBasedComplementAlternatMed.2013;2013:319247.PMID:23662128.

TaoS,ZhengY,LauA,etal.TanshinoneIactivatestheNrf2-dependentantioxidantresponseandprotectsagainstAs(III)-inducedlunginflammationinvitroandinvivo.AntioxidRedoxSignal.2013Nov10;19(14):1647-61.PMID:23394605.

LiY,GongY,LiL,etal.BioactivetanshinoneIinhibitsthegrowthoflungcancerinpartviadownregulationofAuroraAfunction.MolCarcinog.2013Jul;52(7):535-43.PMID:22389266.

LiW,LiJ,AshokM,etal.Acardiovasculardrugrescuesmicefromlethalsepsisbyselectivelyattentuatingalate-actingproinflammatorymediator,highmobilitygroupbox1.JImmunol.2007Mar15;178(6):3856-3864.PMID:17339485.

ZhangY,WonSH,JiangC,etal.TanshinonesfmorChinesemedicinalherbDanshen(SalviamiltiorrhizaBunge)suppressprostatecancergrowthandandrogenreceptorsignaling.PharmRes.2012Jun;29(6):1595-1608.PMID:22281759.


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