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AntibodiesOnline/Ghrelin/obestatin Prepropeptide (GHRL) (Active) Protein/ABIN413323/100 μg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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AntibodiesOnline/Ghrelin/obestatin Prepropeptide (GHRL) (Active) Protein/ABIN413323/100 μg
ProteinName
Ghrelin/obestatinPrepropeptide(GHRL)
  • 2210006E23Rik
  • Ghr
  • MTLRP
  • MTLRPAP
  • m46
  • Gh1-1
  • GRHL
  • MTLRP-AP
  • GHR
  • ghrelin
  • ghrelin-like
  • ghrelin/obestatinpreprohormone
  • ghrelin/obestatinprepropeptide
  • Ghrl
  • LOC100349547
  • ghrl
  • GHRL
Origin
Human
16Human
Source
Escherichiacoli(E.coli)
6Escherichiacoli(E.coli)
2Wheatgerm
1Human
1Synthetic
ProteinType
Native
BiologicalActivity
Active
Application
FunctionalStudies(Func),SDS-PAGE(SDS),WesternBlotting(WB)
Options
Bulkdiscount
Supplier
SupplierProductNo.
PurposePurehumanGherlinforuseinELISA,asapositivecontrolinWesternblotanalysis,orasablockingpeptidetoblockantibodyactivity..
SequenceGS(X)FLSPEHQRVQQRKESKKPPAKLQPRX=serinemodifiedwithn-octanoicacid
BackgroundGhrelin(ghreistheProto-Indo-Europeanrootofthewordgrow)hasbeenidentifiedastheendogenousligandfortheGHS-R(growthhormonesecretagoguesreceptor).Ghrelinisexpressedinthestomach,smallandlargeintestines,andbrainregionsthatareinvolvedintheregulationoffoodintake.BothghrelinandGHS-Rexpressionisalsodetectedintheheart,suggestingthatGhrelinmighthavesomecardiovasculareffects.GhrelinadministrationstimulatesGHsecretionbutalsocausesweightgainbyincreasefoodintake.MaturehumanandratGhrelin(28a.a.)areproducedfroma117aminoacidprecursor.GhrelinhasanunusualmodificationatSer3residuethatisn-octanoylatedandisessentialforbiologicalactivity.Ghrelinisthefirstknownexampleofabioactivepeptidemodifiedbyanacylacid
AlternateNames:Appetite-regulatinghormone,Growthhormonesecretagogue,Growthhormone-releasingpeptide,Motilin-relatedpeptide,ProteinM46HumanGhrelin(Ser3modified),Ghrelin,h-Ghrelin,rh-Ghrelin,recombinanthumanGhrelin,Ghrelin(Ser3modified),recombinantGhrelin,Ghrelin
MolecularWeight3.374kDa
GeneID51738
UniProtQ9UBU3
ResearchAreaCardiovascular,Atherosclerosis,Hormones
PathwaysPositiveRegulationofPeptideHormoneSecretion,HormoneTransport,PeptideHormoneMetabolism,NegativeRegulationofHormoneSecretion,SynapticMembrane,FeedingBehaviour
ApplicationNotesOptimalworkingdilutionshouldbedeterminedbytheinvestigator.
Comment

ActivitySpecification:Biologicalactivityofghrelinhasnotbeenestablished.ThepeptidecanbeusedinELISA,asapositivecontrolinWesternblotanalysis,orasablockingpeptidetoblockantibodyactivity.

RestrictionsForResearchUseonly
FormatLyophilized
ReconstitutionReconstituteinPBScontainingatleast0.1 %BSAtoaconcentrationof1.0 mg/mL.
BufferLyophilizedpeptide
HandlingAdviceCentrifugethevialpriortoopening.
Storage-20°C
StorageComment-20°C
ExpiryDate12months
Productcitedin:Iantorno,Chen,Kim,Tesauro,Lauro,Cardillo,Quon:"GhrelinhasnovelvascularactionsthatmimicPI3-kinase-dependentactionsofinsulintostimulateproductionofNOfromendothelialcells."in:Americanjournalofphysiology.Endocrinologyandmetabolism,Vol.292,Issue3,pp.E756-64,2007(PubMed).


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