ProteoChem/Deuterated Crosslinker DSPd8 50 mg/h5104/50mg

DSP-d8deuteratedcrosslinkingreagent,Dithiobis(succinimidyl2,2,3,3,6,6,7,7-propionate-d8),isacellmembranepermeable,homobifunctional,proteincrosslinkercontainingeightdeuteriumatomstoprovideaneightDaltonshiftbymassspeccomparedtothenon-dueteratedDSP(DSP-d₀).DSP-d8deuteratedcrosslinkingthakesplaceviaamine-reactiveNHSestersatbothendsofacleavable,8-atom(12.0angstrom)spacerarm.Thedeuteratedcrosslinkingspacerarmcontainsareducibledisulfidebond(SS-bond)whichmakesitagoodchoicefornumerousapplicationswherereversiblecrosslinkingisdesired.

UsetheheavyDSP-d8deuteratedproteincrosslinkerincombinationwiththelight,non-deuteratedanalog(DSP-d₀)formassspecstudies.

DSP-d8deuteratedcrosslinkermustbedissolvedinanorganicsolvent,suchasDMSOorDMF,andthenmaybeaddedtoanaqueouscrosslinkingreaction.SinceDSP-d8crosslinkingreagentiscellmembranepermeableitmaybeusedtocrosslinkintracellularproteins.

MolecularWeight:412.46

SpacerLength:12.0Å

Alternativenames:DSP-d₈;D8-DSP;Dithiobis(succinimidylpropionate-d8);DTSP-d8

SpecialbulkpricingisavailableforbulkquantitiesofDSP-d8deuteratedcrosslinkingreagentforyourlargevolumemanufacturingapplication.