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HumaniPSC-DerivedNeuralStemCellsthathavebeengeneticallyeditedusingCRISPR-Cas9technologytointroducetheV337Mmutation(GTG>ATG)intheMAPTgene.ThislineishomozygousfortheV337Mmutationsobothallelescontainthemutation.Clickontheproductimagestoseethedataandfurtherdetails.
TheV337MmutationinMAPThasbeenimplicatedinfrontotemporaldementiaandmayhavearoleinAlzheimersdisease.ThemutationleadstoacceleratedaggregationofMAPT/tauproteinintofilamentstructures(Nacharajuetal.,1999)andmakestheMAPT/tauproteinmoresusceptibletohyperphosphorylation(Alonsoetal.,2004).
| Startingmaterial | Dermalfibroblast |
| Donorgender | Female |
| Donorageatsampling | 64yrs |
| Karyotype | Normal |
| Reprogrammingmethod | Episomalvector |
| Inductionmethod | Monolayer&chemicallydefinedmedium |
| Geneticmodification | HomozygousfortheMAPTV337Mmutation(GTG>ATG) |
| Geneticmodification | Containsapuromycinresistancecassette(intronic) |
| Size | ≥1.5millioncells |
| Kitcomponents | 1vialofNeuralStemCells(≥1.5millioncells)and1bottleofNeuralPlating-XFMedium(30mL) |
| Growthproperties | Adherent |
| Shippingconditions | Dryice |
| Storageconditions | Liquidnitrogen |