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Hello Bio/1Naphthyl PP1/HB0066/50mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Hello Bio/1Naphthyl PP1/HB0066/50mg

Productoverview

  • Name
    1-NaphthylPP1
  • Shortdescription
    Potent,selectivesrcfamilykinaseinhibitor
  • Biologicaldescription
    Potentandselectivesrcfamilykinaseinhibitor,includingv-Srcandc-Fyn.Selectiveforanalogsratherthanwild-typekinase(IC50valuesare1.5nMand1µMforv-Srcanalogversuswild-type).Alsoinhibitsc-AbIandAuroraAkinaseandisapotentPKDinhibitor.Showsanti-canceractions.Cell-permeable.
  • Biologicalaction
    Inhibitor
  • Purity
    >99%
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • MolecularWeight
    317.39
  • Chemicalstructure
    1-Naphthyl PP1 [221243-82-9]
  • MolecularFormula
    C19H19N5
  • CASNumber
    221243-82-9
  • PubChemidentifier
    4877
  • SMILES
    CC(C)(C)N1C2=C(C(=N1)C3=CC=CC4=CC=CC=C43)C(=NC=N2)N

StoringandUsingYourProduct

  • Storageinstructions
    +4°C
  • Solubilityoverview
    solubleinDMSO(20mg/ml)orchloroform
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

Referencesfor1-NaphthylPP1

  • Achemicalswitchforinhibitor-sensitiveallelesofanyproteinkinase.

    BishopACetal(2000)Nature407(6802):395-401.
    PubMedID:11014197
  • Newpyrazolopyrimidineinhibitorsofproteinkinasedaspotentanticanceragentsforprostatecancercells.

    TandonMetal(2013)PLoSOne8(9):e75601.
    PubMedID:24086585
  • AuroraAisinvolvedincentralspindleassemblythroughphosphorylationofSer19inP150Glued.

    ReboutierDetal(2013)JCellBiol201(1):65-79.
    PubMedID:23547029

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