LC Labs/V3579 Venetoclax, Free Base, >99%/V3579/1 g
Venetoclax, also known as ABT-199, is a BCL-2-selective inhibitor. It blocks the growth of BCL-2-dependent tumors in vivo and spares human platelets. A single dose of venetoclax in three patients with refractory chronic lymphocytic leukemia induced tumor lysis within 24 hours. Souers A.J., et al. "ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets." Nat. Med. 19: 202-208 (2013).
The high sensitivity to venetoclax was dependent on human multiple myeloma cell lines (HMCLs) with the CCND1 translocation. Six out of eight CCND1 cell lines were efficiently inhibited by venetoclax with a median LD50 value of 10 nM. Of note, the median venetoclax LD50 of sensitive HMCLs (10 nM) was significantly lower than that of peripheral blood lymphocytes from healthy donors (200 nM). Touzeau C., et al. "The Bcl-2 specific BH3 mimetic ABT-199: a promising targeted therapy for t(11;14) multiple myeloma." Leukemia 28: 210-212 (2014).
Both the BH3 mimetic venetoclax and phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors improved tumor responses to the antiestrogen tamoxifen in estrogen receptor-positive breast cancer. Vaillant F., et al "Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer." Cancer Cell 24: 120-129 (2013).
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This product is offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Sections 55.2(1) and 55.2(6) and other common law exemptions of Canadian patent law; (vi) Section 68B of the Patents Act of 1953 in New Zealand together with the amendment of same by the Statutes Amendment Bill of 2002; (vii) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (viii) such similar laws and rules as may apply in various other countries.
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