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Hycult Biotech/TREM2, Mouse, mAb 6E9/HM1129/100 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Hycult Biotech/TREM2, Mouse, mAb 6E9/HM1129/100 µg

Description:TREM-2,Mouse,mAb6E9

Themonoclonalantibody6E9recognizesmousemembrane-boundaswellassolubletriggeringreceptorexpressedonmyeloidcells-2(TREM-2).TREM-2isa26kDatransmembraneglycoproteinthatconsistsofasingleextracellularimmunoglobulin-likedomain,atransmembraneregionwithachargedlysineresidueandashortcytoplasmictail.ItassociateswithDNAX-activationprotein12(DAP12)forsignalingandfunction.TREM-2isexpressedonimmaturemonocyte-deriveddendriticcells.Afteractivationbymicrobialproductsortumornecrosisfactor(TNF)andTNF-relatedproteins,dendriticcellsdownregulatetheexpressionofTREM-2.TREM-2isalsoexpressedbyosteoclastsandmicroglia,whereitisinvolvedinbonemodelingandbrainfunction,respectively.AnotherroleofTREM-2mightbepromotingtheremovalofapoptoticcells,organicmatrixandmacromoleculesbymicroglia.DefectsinTREM-2areacauseofpolycysticlipomembranousosteodysplasiawithsclerosingleukoencephalopathy(PLOSL),alsocalledpreseniledementiawithbonecystsorNasu-Hakoladisease(NHD).TREM-2,likeTREM-1,canbecleavedonthemembranetoreleaseasolubleformofTREM-2(sTREM-2).ElevatedlevelsofsTREM-2inCSFofmultiplesclerosispatientshavebeendetected.Thiselevatedlevelmayinhibittheanti-inflammatoryfunctionofthemembrane-boundreceptorsuggestingsTREM-2tobeapossibletargetforfuturetherapies.

Specifications:

CatalognumberHM1129
ProducttypeMonoclonalantibodies
Quantity100µg
Formulation1ml(100μg/ml)0.2μmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide.
ApplicationFlowcytometry,Immunoassays,Immunoprecipitation
UseForflowcytometry,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.
ImmunogenMouserecombinantTREM-2protein
IsotypeRatIgG2b
SpeciesMouse
AliasTriggeringreceptorexpressedonmonocytes2,TREM2
ReferencesKoga,Tetal;CostimulatorysignalsmediatedbytheITAMmotifcooperatewithRANKLforbonehomeostasis.Nature2004,428:758
StorageandstabilityProductshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforoneyear.
PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsibleforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct.
DiseaseNeurologicaldisorders

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