企业QQ
官方微信
脂质体ExperimentalStudyofEffectofLiposome-EncapsulatedPreparationsonLensEpithelialCells脂质体剂型药物对晶体上皮细胞作用的实验研究短句来源ObjectiveToexaminetheretinaltoxicityofliposome-encapsulated5-fluorouracil(5-FU)administeredintravitreallyandtheinhibitingeffectsontheproliferativevitreoretinopathy(PVR)inananimalmodel.目的研究玻璃体内注射5-氟尿嘧啶(5-fluorouracil，5-FU)脂质体对视网膜的毒性作用，及其对动物模型的增生性玻璃体视网膜病变(proliferativevitreoretinopathy,PVR)的防治效果。短句来源MethodsLiposome-encapsulated5-FUwaspreparedinfourdifferentconcentrationof0.8,1.6,3.2,and6.0mg,0.1mL.18whiterabbits(36eyes)weredividedinto6groupof3animalseach(6eyes).方法一、家兔18只共36只眼，分3组：5-氟尿嘧啶脂质体组，浓度分别为0.8mg／0.1mL,1.6mg／0.1mL,3.2mg／0.1mL，6.0mg／0.1mL；短句来源Liposome-Encapsulated5-FluorouracilintheTreatmentofExperimentalProliferativeVitreoretinopathy5-氟尿嘧啶脂质体防治增生性玻璃体视网膜病变的实验研究短句来源ConclusionLiposome-encapsulated5-FUmaymarkedlyreducetheretinaltoxicityandtherateofretinaldetachmentinPVRmodelafterintravitrealinjection.一次性玻璃体内注射5-氟尿嘧啶脂质体能有效抑制玻璃体视网膜病变的发展，显著降低增生性玻璃体视网膜病变动物模型牵引性视网膜脱离的发生率。短句来源更多“liposome-encapsulated”译为未确定词的双语例句Liposome-encapsulatedDaunomycinandItsClearancefromtheVitreousandTcxicitytotheRetina道诺霉素脂质体玻璃体内代谢及视网膜毒性短句来源Intravitrealphannacokineticsofliposome-encapsulatedamikacinanddexamethasoneinarabbitmodel丁胺卡那霉素地塞米松复方脂质体在兔眼玻璃体内的药代动力学研究短句来源
查询“liposome-encapsulated”译词为用户自定义的双语例句
为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法，我们为您准备了出自英文原文的大量英语例句，供您参考。liposome-encapsulatedTheinvivoeliminationofmacrophageswasachievedbyuseofliposome-encapsulateddrugdichloromethylenediphosphonate.InhibitionofTrachealVascularExtravasationbyLiposome-EncapsulatedAlbuterolinRatsStudieswithamixtureof40%liposome-encapsulatedand60%solubleIL-7gaveanintermediateresponsebetweenthatofsolubleIL-7andthatofliposome-encapsulatedIL-7.Thebioavailabilityofliposome-encapsulatedIL-7wascomparabletothatofsolubleIL-7,asdeterminedbybothbloodandurinarydata.Anequivalentsubcutaneousdoseofliposome-encapsulatedIL-7resultedinapeaklevellessthanone-tenththatseenwithsolubledrugbutproducedsustainedbloodandurinarylevelsfor5days.更多
Liposome-encapsulatedpreparationscontainimgHomobarringtonine(HH),5-Fluorouracil(5-FU),Adriacin(ADM)andDexamethasone(DXT)wereinjectedtothecapsularbagofrabbiteyesrightafterlensextracapsularextraction.Theresultshowedthattheliposome-encapsulatedpreparationofdifferentdrugscouldreleaseslowlyfortwoweeks.Noproliferationwasfoundunderlightmicroscopebutswellingofmitochondriaandvacuolationformationincytoplasmwerefoundunderelectronmicroscopeinlensepithelialcells...
Liposome-encapsulatedpreparationscontainimgHomobarringtonine(HH),5-Fluorouracil(5-FU),Adriacin(ADM)andDexamethasone(DXT)wereinjectedtothecapsularbagofrabbiteyesrightafterlensextracapsularextraction.Theresultshowedthattheliposome-encapsulatedpreparationofdifferentdrugscouldreleaseslowlyfortwoweeks.NoproliferationwasfoundunderlightmicroscopebutswellingofmitochondriaandvacuolationformationincytoplasmwerefoundunderelectronmicroscopeinlensepithelialcellsinHH,5-FUandADMtreatedgroups,whichweresignificantlydifferentfromthatinDXTandcontrolgroups(P>0.01).Therewasnosignificantdifferenceofthepostoperativecornealthicknessorendothelialdensityamongallliposome-encapsulateddrugsandcontrolgroups.
本研究通过应用脂质体剂型包裹抗代谢药物注入晶体囊外摘除术后的晶体囊袋内，观察药物在眼内的释放及对晶体上皮细胞的作用，探索药物防治后发性白内障的可能性。结果显示：（１）采用脂质体剂型包裹高三尖杉酯碱（ＨＨ）、氟尿嘧啶（ＦＵ）、阿霉素（ＡＤＭ）、地塞米松（ＤＸＴ）可以在眼内缓慢释放；（２）眼内缓慢释放时间为２周；对晶体上皮细胞作用显效时间达４周：光镜下表明ＦＵ、ＨＨ、ＡＤＭ组能抑制残留晶体上皮细胞的增殖；电镜下可见细胞浆空泡变性、线粒体肿胀等形态改变，与对照组、ＤＸＴ组间有显著性差异（Ｐ＜０．０１）；（３）所有脂质体剂型药物组与对照组在手术后对角膜厚度、内皮细胞的数量和形态的影响均无显著性差异（Ｐ＞０．０５）。
Purpose:Toinvestigatethemethodofdeterminationtheconcentrationofdaunoru-bicine(DNR)andliposomeencapsulateddaunorubicine(LDNR)ofaqueoushumorinrabbiteyes.
目的:探讨药物柔红霉素(daunorubicine,DNR)及其脂质体在房水中维持的浓度及时间。方法:20只兔眼于晶体囊外摘除术中分别注入0.1ml之1mg/mlDNR及其脂质体(LDNR),术后12、24、48小时和1周时间采集房水,应用高效液相色谱法测定房水中DNR的浓度。结果:术后12、24、48小时注入DNR和LDNR眼均可测出DNR,且LDNR眼浓度明显高于DNR眼,术后1周LDNR眼仍可测出DNR,但注入DNR眼无法测出。结论:应用高效液相色谱法可测定兔房水中的DNR浓度,且LDNR眼浓度明显高于DNR眼,有明显的缓释延时效应。眼科学报1998;14:232～235。
ObjectiveToinvestigatetheeffectofliposomeencapsulatedtotalalkaloidofharmaline(LTAH)onlensepithelialcells(LEC)andpreventingtheformationofposteriorcapsuleopacification(PCO)MethodsLTAHwaspreparedbymodifiedfreezethawingmethod.0.1mlLTAH(0.2g/L)wereinjectedintothecapsularbagduringextracapsularlensextraction(ECLE)of10rabbiteyes.Dataonintraocularpressure,densityofcornealendothelialcells,thebwave...
ObjectiveToinvestigatetheeffectofliposomeencapsulatedtotalalkaloidofharmaline(LTAH)onlensepithelialcells(LEC)andpreventingtheformationofposteriorcapsuleopacification(PCO)MethodsLTAHwaspreparedbymodifiedfreezethawingmethod.0.1mlLTAH(0.2g/L)wereinjectedintothecapsularbagduringextracapsularlensextraction(ECLE)of10rabbiteyes.Dataonintraocularpressure,densityofcornealendothelialcells,thebwaveofERGaswellasthehistopathologicalexaminationwerecollected.ResultsPCOformationwasfoundbothinTAHtreatedandcontrolgroupby4weeks,however,itwasmuchmilderinLTAHgroup.Therewasnodifferenceinthedensityofcornealendothelialcells,theamplitudeandlatencyofbwaveofERGbetweentheLTAHeyes,andcontroleyes.HistopathologicalstudyrevealedthatLECproliferationoccuredby4weeksandSoemmeringringformationby8weeksincontrols,onlymildvacuolizationofLECwasnotedintheLTAHandTAHtreatedeyes.ConclusionTheresultssuggestthatLTAHorTAHcouldinhibitproliferationofLECswithoutdefinitetoxicity,thereforeitmaybeusedasapotentialagentinpreventingthedevelopmentofPCO.
目的探讨骆驼蓬总碱（ＴＡＨ）及其脂质体（ＬＴＡＨ）对兔后囊混浊（ＰＣＯ）形成的影响。方法用改良冻融法制备ＬＴＡＨ。１０只健康纯种新西兰白兔分别每眼行晶状体囊外摘出术并分别注入０１ｍｌ浓度为０２ｍｇ／ｍｌＴＡＨ及ＬＴＡＨ。观察术后后囊、手术前后眼压、角膜内皮细胞、视网膜电图及组织病理学变化。结果注药术后４周实验眼与对照眼角膜内皮细胞密度及形态、视网膜电图的ｂ波振幅及潜时无明显差别。组织病理学检查显示对照组眼明显残留晶状体上皮细胞（ＬＥＣ）增生并有Ｓｏｅｍｍｅｒｉｎｇ环形成，而用药眼无明显的残留ＬＥＣ增殖且细胞空泡变性。结论ＴＡＨ及ＬＴＡＨ能抑制兔眼残留ＬＥＣ增殖，有可能成为一种预防后发性白内障的药物。