Liposome coated stents: a method to deliver drugs to the site of action and improve stent bloodcompatibility. PubMed.cn

JLiposomeRes2006;16(3):303-9.全文索取Liposomecoatedstents:amethodtodeliverdrugstothesiteofactionandimprovestentblood-compatibility.
AntimisiarisSG,KoromilaG,MichanetzisG,MissirlisYF.

Abstract
Amethodtocorrectstentrelatedcomplicationsnon-invasively,isthelocaldeliveryoftherapeuticagents.Differentdrugshavebeendeliveredonstents,afterbeingeitherdispersedorencapsulatedinpolymericmaterials,andplacedonstentstoformdrug-eluting-stents(DE-stents).Investigationofpossibilitytocoverpolymer-coatedmetallicstents,withliposomaldrugs,forpreparationofnovelDE-liposome-coated-stents,hasbeeninitiatedfewyearsago.Inthiscontextourresearchhasbeenfocusedonansweringthefollowingquestions:(i)Canliposomesbeappliedascoatingsonpolymercoveredstents?(ii)Candrugreleasefromliposomecoated-stentsbecontrolled?And:(iii)howishaemo-compatibilityofstentsaffected?Theresultsoftheexperimentscarriedoutdemonstratethatliposomalformulationsofdrugscanbeusedascoatingsystemsofpolymercoveredstentsforachievingsustainedreleaseofdrugsatthesiteofinterest.Bymodifyingliposomecharacteristics,differentamountsofdrugsmaybeplacedonthestentsandtheirreleaseratescanbeadjustedformaximumtherapeuticbenefit.Finally,haemocompatibilityofstentsishighlyimproved(mainlyintermsofcelladhesionandactivationofcoagulationsystem),whenstentsarecoatedwithheparin-encapsulating-DRVliposomes.

PMID:16952883[Pubmed-MEDLINE]