JPT/CMV Dextramer Package 1FITC/CMVPACKFITC/

CMVDextramerPackage1-FITC

ProductCode:CMV-PACK-FITC

Packageof8carefullyselectedCMVspecificMHCIDextramers(+1control),forsensitiveandspecificdetectionofantigen-specificTcellsusingflowcytometry.EachmulitmerisFITClabeled.
Amount:9x50tests
Application(s):Cellularimmuneresponse,Immunemonitoring,T-cellassays
Indication(s)/Topic(s):Vaccination,Infection,Control,Cancer,TORCH,Infectiousmononucleosis,CMVhepatitis,Retinitis,Colitis,Pneumonitis,Esophagitis,AIDS,Cancerchemotherapy,Transplantation
DeliveryTime:10-12days

MHCIDextramerCollections
MHCIDextramerscombineadextranpolymerbackbonewithahighnumberofMHCandfluorochromemoleculesprovidingmulitplebindingdomainsforantigen-specificTcellreceptorbinding.Thisenhancestheirstainingintensityandincreasesresolutionaswellassignal-to-noiseratiowithminimalbackgroundstaining.Inaddition,thedextranbackbonestabilizestheMHC-peptidecomplexesandfluorochromes.TheCMVsetisusefulforenumerationofCMV-specificCD8+Tcells,e.g.forimmunemonitoringinimmune-compromisedindividualsfollowingtransplantation,testingofvirus-specificvaccinesorprofilingofvirus-specificTcellresponses.TheDextramersareprovidedasFITCconjugates.

Thefollowing9DextramersareprovidedwithFITClabel

Dextramer:HLA-A*0101/VTEHDTLLY-Antigen:pp50
Dextramer:HLA-A*0201/NLVPMVATV-Antigen:pp65
Dextramer:HLA-A*0301/KLGGALQAK-Antigen:IE-1
Dextramer:HLA-A*2402/QYDPVAALF-Antigen:pp65
Dextramer:HLA-B*0702/RPHERNGFTVL-Antigen:pp65
Dextramer:HLA-B*0702/TPRVTGGGAM-Antigen:pp65
Dextramer:HLA-B*0801/ELRRKMMYM-Antigen:pp65
Dextramer:HLA-B*3501/IPSINVHHY-Antigen:pp65
Dextramer:General/NegativeControl

BenefitsofMHCIDextramers®
-MoreMHCmoleculesandmorefluorochromesthanconventionalMHCmultimers
-Highersensitivity(importantforlow-affinityepitopesascommonlyfoundincancer&autoimmunedisease)
-Highstability
-Custom-madeDextramersavailableuponrequest

CMVDextramerPackage1-FITC

SelectedReferencesforMHCIDextramers®
"CombinationImmunotherapyafterASCTforMultipleMyelomaUsingMAGE-A3/Poly-ICLCImmunizationsFollowedbyAdoptiveTransferofVaccine-PrimedandCostimulatedAutologousTCells"
Rapoportetal.,ClinCancerRes(2014)-PMID:24520093
"MolecularImprintofExposuretoNaturallyOccurringGeneticVariantsofHumanCytomegalovirusontheTcellRepertoire"
Smithetal.,SciRep(2014)-PMID:24509977
"ProbingtheeffectorandsuppressivefunctionsofhumanTcellsubsetsusingantigen-specificengineeredTcellreceptors"
Wanetal.,PLoSOne(2013)Fulltext
"HumanNaturalKillerCellsPreventInfectiousMononucleosisFeaturesbyTargetingLyticEpstein-BarrVirusInfection"
Chijiokeetal.,CellRep(2013)-PMID:24360958