JPT/EBV Dextramer Package 1APC/RX05APC/

EBVDextramerPackage1-APC

ProductCode:RX05-APC

Packageof4carefullyselectedEBVspecificMHCIDextramers(+1control),forsensitiveandspecificdetectionofantigen-specificTcellsusingflowcytometry.EachmulitmerisAPClabeled.
Amount:5x50tests
Application(s):Cellularimmuneresponse,Immunemonitoring,T-cellassays
Indication(s)/Topic(s):Infection,Cancer,Hodgkinslymphoma,Burkittslymphoma,Nasopharyngealcarcinoma,Dermatomyositis,Systemiclupuserythematosus,Rheumatoidarthritis,Sjgrenssyndrome,Multiplesclerosis
DeliveryTime:10-12days

MHCIDextramerCollections
MHCIDextramerscombineadextranpolymerbackbonewithahighnumberofMHCandfluorochromemoleculesprovidingmulitplebindingdomainsforantigen-specificTcellreceptorbinding.Thisenhancestheirstainingintensityandincreasesresolutionaswellassignal-to-noiseratiowithminimalbackgroundstaining.Inaddition,thedextranbackbonestabilizestheMHC-peptidecomplexesandfluorochromes.TheEBVsetisusefulforenumerationofEBV-specificCD8+Tcells,e.g.forimmunemonitoringinimmune-compromisedindividualsfollowingtransplantation,testingofvirus-specificvaccinesorprofilingofvirus-specificTcellresponses.TheDextramersareprovidedasAPCconjugates.

Thefollowing5DextramersareprovidedwithAPClabel

Dextramer:HLA-A*0201/GLCTLVAML-Antigen:BMLF-1
Dextramer:HLA-B*3501/HPVGEADYFEY-Antigen:EBNA-1
Dextramer:HLA-B*0702/RPPIFIRRL-Antigen:EBNA-3A
Dextramer:HLA-B*0801/FLRGRAYGL-Antigen:EBNA-3A
Dextramer:General/NegativeControl

BenefitsofMHCIDextramers®
-MoreMHCmoleculesandmorefluorochromesthanconventionalMHCmultimers
-Highersensitivity(importantforlow-affinityepitopesascommonlyfoundincancer&autoimmunedisease)
-Highstability
-Custom-madeDextramersavailableuponrequest

EBVDextramerPackage1-APC

SelectedReferencesforMHCIDextramers®
"CombinationImmunotherapyafterASCTforMultipleMyelomaUsingMAGE-A3/Poly-ICLCImmunizationsFollowedbyAdoptiveTransferofVaccine-PrimedandCostimulatedAutologousTCells"
Rapoportetal.,ClinCancerRes(2014)-PMID:24520093
"MolecularImprintofExposuretoNaturallyOccurringGeneticVariantsofHumanCytomegalovirusontheTcellRepertoire"
Smithetal.,SciRep(2014)-PMID:24509977
"ProbingtheeffectorandsuppressivefunctionsofhumanTcellsubsetsusingantigen-specificengineeredTcellreceptors"
Wanetal.,PLoSOne(2013)Fulltext
"HumanNaturalKillerCellsPreventInfectiousMononucleosisFeaturesbyTargetingLyticEpstein-BarrVirusInfection"
Chijiokeetal.,CellRep(2013)-PMID:24360958