Na+ channel activator. Binds to active channels and prevents the inactive state. Increases persistent sodium current and intracellular Ca2+. Increases reverse Na+ / Ca2+ exchange current, pump activity and exocytosis. Induces action potentials and extended membrane depolarization.
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Veratridine
Effects of veratridine on sodium currents and fluxes.
Ulbricht W (1998)Rev Physiol Biochem Pharmacol 133 : 1-54.
PubMedID: 9600010
Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy.
Fekete A et al (2009)J Neurochem 111(3) : 745-56.
PubMedID: 19719824
Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine.
Maroto R et al (1994)Eur J Pharmacol 270(4) : 331-9.
PubMedID: 7805782
[Involvement of veratridine-induced increase of reverse Na(+)/Ca(2+) exchange current in intracellular Ca(2+) overload and extension of action potential duration in rabbit ventricular myocytes].
Kong LH et al (2012)Sheng Li Xue Bao 64(4) : 433-43.
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