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Product overview

  • Name
    (S)-MCPG
  • Short description
    Non-selective group I/II mGluR antagonist
  • Biological description

    Non-selective group I and II mGluR antagonist. Water soluble sodium salt.

    Active enantiomer of (R,S)-MCPG.


    Displays slight activity at mGlu8 receptor but none at mGlu4 receptor.

    Inhibits MF-LTP (mossy fiber long term potentiation) and blocks induction of LTP in CA1 of rat hippocampus.


    Water soluble (R,S)-MCPG sodium salt and (S)-MCPG sodium salt also available.

  • Alternative names
    (S)-M4CPG
  • Biological action
    Antagonist
  • Purity
    >99%
  • Our products in action
    Submit Your Citation Now

Properties

  • Chemical name
    (S)-α-Methyl-4-carboxyphenylglycine
  • Molecular Weight
    209.2
  • Chemical structure
    (S)-MCPG [150145-89-4]
  • Molecular Formula
    C10H11NO4
  • CAS Number
    150145-89-4
  • PubChem identifier
    446355
  • SMILES
    C[C@](C1=CC=C(C=C1)C(=O)O)(C(=O)O)N
  • Source
    Synthetic
  • InChi
    InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h4-5H,11H2,1H3,(H,12,13)(H,14,15)/t10-/m0/s1
  • InChiKey
    DNCAZYRLRMTVSF-JTQLQIEISA-N
  • MDL number
    MFCD00216858
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in 0.1M NaOH (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for (S)-MCPG

  • Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs).

    Bedingfield JS et al (1995)Br J Pharmacol 116(8) : 3323-9.
    PubMedID: 8719814

  • Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes.

    Sekiyama N et al (1996)Br J Pharmacol 117(7) : 1493-503.
    PubMedID: 8730745

  • Pharmacological agents acting at subtypes of metabotropic glutamate receptors.

    Schoepp DD et al (1999)Neuropharmacology 38(10) : 1431-76.
    PubMedID: 10530808

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