ImmunohistochemistryServicesWorkwithLifeSpantodesignacustomimmunohistochemistrytoaddressyourspecificbiologicalquestion.Outsourcetheentirelocalizationprocesswithouthavingtoworryaboutfindingandcharacterizingtargetspecificantibodies,sourcingandvalidatingdifficult-to-findtissues,andhavingtheabilitytointerprettheresultingimmunostaininginrelationtocomplexhumanpathologies.TCRScreeningServicesTestyourtherapeuticantibodiesinimmunohistochemistryagainstabroadpanelofnormalfrozenhumantissuetypesinordertodeterminepotentialunintendedbinding.Ournon-GLPTCRservicesaredesignedontheFDArecommendationoutlinedintheir"PointstoConsiderintheManufactureandTestingofMonoclonalAntibodyProductsforHumanUse".
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PathPlus™PolyclonalRabbitanti‑HumanSIPR3/EDG3/S1P3Antibody(N‑Terminus,IHC)LS‑A1030
PathPlus™PolyclonalRabbitanti‑HumanSIPR3/EDG3/S1P3Antibody(N‑Terminus,IHC)LS‑A1030
International
206-374-1102ForResearchUseOnly
DescriptionS1PR3isareceptorforthelysosphingolipidsphingosine1-phosphate(S1P).S1Pisabioactivelysophospholipidthatelicitsdiversephysiologicaleffectonmosttypesofcellsandtissues.Itisthoughttoparticipateinregulatingvascularendothelialcellfunctionandangiogenesis.WhenexpressedinratHTC4hepatomacells,itiscapableofmediatingS1P-inducedcellproliferationandthesuppressionofapoptosis.MetastaticcancersinthebraincanoverexpressS1PR3aspartoftheneuroinflammatoryresponse,anditisimplicatedinregulatingbloodbrainbarrierpermeability.Inimmunohistochemistry,ithasvariablemembranouspositivityinmosttissuesthroughoutthebody.References:NatCommun9,2705(2018)doi:10.1038/s41467-018-05030-w
SynonymsS1PR3|EDG-3|EDG3|LPB3|S1PreceptorEDG3|S1P3|S1PreceptorEdg-3|S1Preceptor3
PerformingIHC?SeeourcompletelineofImmunohistochemistryReagentsincludingantigenretrievalsolutions,blockingagentsABCDetectionKitsandpolymers,biotinylatedsecondaryantibodies,substratesandmore.
ImmunogenSynthetic16aminoacidpeptidefromN-TerminusextracellulardomainofhumanEDG3/S1P3.PercentidentitywithotherspeciesbyBLASTanalysis:Human,Gibbon,Monkey(93%);Gorilla,Marmoset(87%);Rabbit(80%).
LS-E28102-Liquid-50g-$145.00
ImmunizingpeptideusedtogenerateLS-A1030.Usefulforpre-absorptionandneutralizationoftheantibodysantigenbindingsite.
SpecificityHumanEDG3/S1P3.BLASTanalysisofthepeptideimmunogenshowednohomologywithotherhumanproteins.
StorageAliquotandstoreundilutedat-20Corbelowforupto1year.Canbestoredundilutedat4Cforupto1month.Avoidfreeze-thawcycles.
ThisantibodycarriestheLSBio100%Guarantee.LSBioGuarantee
Anti-EDG3/S1P3antibodyIHCofhumankidney.Immunohistochemistryofformalin-fixed,paraffin-embeddedtissueafterheat-inducedantigenretrieval.
Anti-EDG3/S1P3antibodyIHCofhumankidney.Immunohistochemistryofformalin-fixed,paraffin-embeddedtissueafterheat-inducedantigenretrieval.
PathPlus™SIPR3/EDG3/S1P3Antibody(N-Terminus)forIHCLS-A1030hasanLSBioRatingof(5.0)Rating
