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Lifespan/PathPlus™ EDNRB / Endothelin B Receptor Antibody N‑Terminus Polyclonal IHC LS‑A56/50 µg (1 mg/ml)/LS-A56-50188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Lifespan/PathPlus™ EDNRB / Endothelin B Receptor Antibody N‑Terminus Polyclonal IHC LS‑A56/50 µg (1 mg/ml)/LS-A56-50

Specifications

Description
EndothelinreceptortypeB(EDNRB)isexpressedinmosttissues.MutationsinthisreceptorareresponsIBLeforHirschsprungdiseasetype2,amultigenicdisorderwithphenotypessuchasbicoloredirides,megacolon,hypopigmentation,andhearingloss.EDNRBhassimilaraffinityforallthreeendothelinsandactivatesaphosphatidylinositol-calciumsecondmessengersystem.Asplicevariant,termedSVR,hasbeendescribed;thesequenceoftheETB-SVRreceptorisidenticaltoET-Breceptor,withtheexceptionoftheintracellularC-terminaldomain.WhilebothsplicevariantsbindendothelinET1,theyexhibitdifferentresponses,whichsuggeststhattheymaybefunctionallydistinct.TheUniProtConsortium.NucleicAcidsRes.47:D506-515(2019);NucleicAcidsRes.2016Jan4;44(D1):D733-45,PMID:26553804
Target
HumanEDNRB/EndothelinBReceptor
SeeAllEDNRB/EndothelinBReceptorAntibodies
Host
Rabbit
Reactivity
Human,Monkey(testedor100%immunogensequenceidentity)
Clonality
Polyclonal
Conjugations
Unconjugated.AlsoavailableconjugatedwithAP,APC,Biotin,FITC,HRP,PE.
Purification
Immunoaffinitypurified
Modifications
Unmodified
Applications
  • IHC
  • IHC-Paraffin(4µg/ml)
  • Applicationstestedforthebaseformofthisproductonly
PerformingIHC?SeeourcompletelineofImmunohistochemistryReagentsincludingantigenretrievalsolutions,blockingagentsABCDetectionKitsandpolymers,biotinylatedsecondaryantibodies,substratesandmore.
Immunogen
Synthetic17aminoacidpeptidefromN-TerminusextracellulardomainofhumanEDNRB.PercentidentitywithotherspeciesbyBLASTanalysis:Human,Gorilla,Monkey(100%);Gibbon(94%);Dog(88%);Marmoset,Goat,Bovine(82%).
BlockingPeptide
LS-E29082-Liquid-50µg-$145.00ImmunizingpeptideusedtogenerateLS-A56.Usefulforpre-absorptionandneutralizationoftheantibody'santigenbindingsite.
Epitope
N-Terminus
Specificity
HumanEDNRB.BLASTanalysisofthepeptideimmunogenshowednohomologywithotherhumanproteins.
Presentation
PBS,0.1%SodiumAzide
Storage
Aliquotandstoreundilutedat-20°Corbelowforupto1year.Canbestoredundilutedat4°Cforupto1month.Avoidfreeze-thawcycles.
Restrictions
Forresearchuseonly.
Guarantee
ThisantibodycarriestheLSBIo100%Guarantee.
LSBioGuarantee
AboutEDNRB/EndothelinBReceptor
P24530NM_000115NP_000106.1

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