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Medimabs/Substance P Rat Monoclonal Antibody (NC1/34)/MM00011 antiSubstance P/0.5 mL
Product Name
Substance P Rat Monoclonal Antibody (NC1/34)
Host
Rat
Clonality
Monoclonal
Research Area(s)
Neuroscience, Cancer, Metabolism
Immunogen
Substance P
Clone ID
NC1/34
DataSHEET
View Datasheet (PDF)
Isotype
IgG2a
Conjugation
None
Reactivity
This antibody recognizes the COOH-terminal end of substance P. It does not recognize Leu- or Met enkephalin, somatostatin or beta-endorphin; cross-reactivity with eledoisin: 5%. It recognizes Substance P in postmortem tissue of the human brain.
Specificity
predicted to all mammalian species, crab and pigeon
Storage Buffer
Tissue culture supernatant
Format
0.5 mL
Background
The discovery of substance P (SP) was reported in 1931. After more than 70 years of investigation, SP is perhaps the best understood neuropeptide transmitter. Substance P is an undecapeptide, which by the mid-1980s was recognized to belong to the tachykinin peptide family; it is also member of the neurokinins. It has been proposed that SP, released from primary afferent nerve endings, plays a role in chronic inflammation and pain. Neurotransmitters appear to play a key role in the regulation of emotions and antagonists of their receptors may be novel psychotropic drugs of the future.
