SignaGen 是一家专注于开发和生产基因转导工具的企业，服务于生物医学研究领域。借助我们独有的技术平台（美国专利商标局号码为 072308 和 61135606），SignaGen 已经成功开发出三大类 DNA/siRNA 转染试剂，经验证我们的产品比市场上主导产品效率更高，细胞毒性更低。更重要的是我们提供一个合理的价位。

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1. Bindocci E, Savtchouk I, Liaudet N, Becker D, Carriero G, Volterra A. Three-dimensional Ca2+ imaging advances understanding of astrocyte biology.  Science. 2017; 356(6339). pii: eaai8185.
2. Eyquem J, Mansilla-Soto J, Giavridis T, van der Stegen SJ, Hamieh M, Cunanan KM, Odak A, Gönen M, Sadelain M. Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection.  Nature. 2017; 543(7643): 113 ~ 117.
3. Celona B, Dollen JV, Vatsavayai SC, Kashima R, Johnson JR, Tang AA, Hata A, Miller BL, Huang EJ, Krogan NJ, Seeley WW, Black BL1,5. Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106.  Elife. 2017 Jan 10;6. pii: e19032. doi: 10.7554/eLife.19032.
4. Arora P, Basu A, Schmidt ML, Clark GJ, Donninger H, Nichols DB, Calvisi DF, Kaushik-Basu N. Nonstructural protein 5B promotes degradation of the NORE1A tumor suppressor to facilitate hepatitis C virus replication. Hepatology. 2017 Jan 16. doi: 10.1002/hep.29049. [Epub ahead of print]
5. Okoreeh AK, Bake S, Sohrabji F. Astrocyte-specific insulin-like growth factor-1 gene transfer in aging female rats improves stroke outcomes. Glia. 2017 Mar 20. doi: 10.1002/glia.23142. [Epub ahead of print]
6. Tang FH, Hsieh TH, Hsu CY, Lin HY, Long CY, Cheng KH, Tsai EM. KRAS mutation coupled with p53 loss is sufficient to induce ovarian carcinosarcomas in mice.  Int J Cancer. 2017; 140(8): 1860 ~ 1869.
7. Tian X, Ohmura T, Shah AS, Son S, Tian Y, Birukova AA.  Role of End Binding Protein-1 in endothelial permeability response to barrier-disruptive and barrier-enhancing agonists.  Cell Signal. 2017; 29: 1 ~ 11.
8. Fan W, Xie J, Xia J, Zhang Y, Yang M, Wang H, Pan Y, Zhang M, Han B, Wu B, Hou Z, Liang D, Wang C, Xu J, Song L, Liu Q. RUVBL1-ITFG1 interaction is required for collective invasion in breast cancer. Biochim Biophys Acta. 2017; S0304-4165(17)30099-5.
9. Qin X, Chen J, Wu L, Liu Z.  MiR-30b-5p acts as a tumor suppressor, repressing cell proliferation and cell cycle in human hepatocellular carcinoma.  Biomed Pharmacother. 2017; 89: 742 ~ 750.
10. Li D, Cheng M, Niu Y, Chi X, Liu X, Fan J, Fan H, Chang Y, Yang W. Identification of a novel human long non-coding RNA that regulates hepatic lipid metabolism by inhibiting SREBP-1c.  Int J Biol Sci. 2017; 13(3): 349 ~ 357.
11. Cho NW, Lampson MA, Greenberg RA.  In vivo imaging of DNA double-strand break induced telomere mobility during alternative lengthening of telomeres.  Methods. 2017; 114: 54 ~ 59.
12. Posternak V, Ung MH, Cheng C, Cole MD.  MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase.  Mol Cancer Res. 2017; 15(2): 213 ~ 224.
13. Li Y, Wang L, Zhou L, Song Y, Ma S, Yu C, Zhao J, Xu C, Gao L.  Mol Cell Endocrinol. 2017; 446: 70 ~ 80.
14. Su Z, Zheng X, Zhang X, Wang Y, Zhu S, Lu F, Qu J, Hou L. Sox10 regulates skin melanocyte proliferation by activating the DNA replication licensing factor MCM5.  J Dermatol Sci. 2017; 85(3): 216 ~ 225.
15. Shukla S, Elson G, Blackshear PJ, Lutz CS, Leibovich SJ.  3UTR AU-Rich Elements (AREs) and the RNA-Binding Protein Tristetraprolin (TTP) Are Not Required for the LPS-Mediated Destabilization of Phospholipase-Cβ-2 mRNA in Murine Macrophages.  Inflammation. 2017; 40(2): 645 ~ 656.
16. Yang S, Qiang L, Sample A, Shah P, He YY.  NF-κB Signaling Activation Induced by Chloroquine Requires Autophagosome, p62 Protein, and c-Jun N-terminal Kinase (JNK) Signaling and Promotes Tumor Cell Resistance.  J Biol Chem. 2017; 292(8): 3379 ~ 3388.
17. Wu YP, Wu YF, Zhang C, Zhou HB, Cao C1, Li M, Zhu C, Ying SM, Chen ZH, Shen HH, Li W.  Activating Transcription Factor 3 Is Essential for Cigarette Smoke-Induced Mucin Expression via Interaction with Activator Protein-1.  Am J Pathol. 2017; 187(2): 280 ~ 291.
18. Shiu TY, Shih YL, Feng AC, Lin HH, Huang SM, Huang TY, Hsieh CB, Chang WK, Hsieh TY.  HCV core inhibits hepatocellular carcinoma cell replicative senescence through downregulating microRNA-138 expression.  J Mol Med (Berl). 2017 Mar 3. doi: 10.1007/s00109-017-1518-4. [Epub ahead of print]
19. Su CH, Hung KY, Hung SC, Tarn WY.  RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M.  Mol Cell Biol. 2017; 37(3). pii: e00466-16.
20. Yang Z, Kim S, Mahajan S, Zamani A and Faccio R. Phospholipase C{gamma}1 (PLC{gamma}1) Controls Osteoclast Numbers via Colony-stimulating Factor 1 (CSF-1)-dependent Diacylglycerol/β-Catenin/CyclinD1 Pathway. J. Biol. Chem., 2017; 292: 1178 ~ 1186.
21. Hilterbrand AT, Boutz DR, Marcotte EM, Upton JW and Biron CA. Murine Cytomegalovirus Deubiquitinase Regulates Viral Chemokine Levels To Control Inflammation and Pathogenesis.  mBio, 2017; 8: e01864 ~ 16.
22. Bernichtein S, Pigat N, Barry Delongchamps N, Boutillon F, Verkarre V, Camparo P, Reyes-Gomez E, Méjean A, Oudard SM, Lepicard EM, Viltard M, Souberbielle JC, Friedlander G, Capiod T, Goffin V. Vitamin D3 Prevents Calcium-Induced Progression of Early-Stage Prostate Tumors by Counteracting TRPC6 and Calcium Sensing Receptor Upregulation. Cancer Res. 2017; 77: 355 ~ 365.
23. Eclov RJ, Kim M1, Smith R1, Liang 1, Ahituv 1, Kroetz D2.  In Vivo Hepatic Enhancer Elements in the Human ABCG2 Locus.  Drug Metab Dispos. 2017; 45(2): 208 ~ 215.
24. Chun H, Sharma AK, Lee J, Chan J, Jia S, Kim BE.  The Intestinal Copper Exporter CUA-1 Is Required for Systemic Copper Homeostasis in Caenorhabditis elegans.  J Biol Chem. 2017; 292(1): 1 ~ 14.
25. Hong AW, Meng Z, Yuan HX, Plouffe SW, Moon S, Kim W, Jho EH, Guan K4. Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP. EMBO Rep. 2017; 18(1): 72 ~ 86.
26. Choi YB, Shembade N, Parvatiyar K, Balachandran S, Harhaj EW. TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS. Mol Cell Biol. 2016; 37(1): e00422-16.
27. Deng X, Xu P, Zou W, Shen W, Peng J, Liu K, Engelhardt JF, Yan Z, Qiu J.  DNA Damage Signaling Is Required for Replication of Human Bocavirus 1 DNA in Dividing HEK293 Cells.  J Virol. 2017; 91(1): e01831-16.
28. Pourshafie N, Lee PR, Chen KL, Harmison GG, Bott LC, Katsuno M, Sobue G, Burnett BG, Fischbeck KH, Rinaldi C. MiR-298 Counteracts Mutant Androgen Receptor Toxicity in Spinal and Bulbar Muscular Atrophy. Mol Ther. 2016; 24(5): 937 ~ 45.
29. Arias JF, Colomer-Lluch M, von Bredow B, Greene JM, MacDonald J, OConnor DH, Serra-Moreno R, Evans DT. Tetherin Antagonism by HIV-1 Group M Nef Proteins.  J Virol. 2016; 90: 10701 ~ 10714.
30. Durbin AF, Wang C, Marcotrigiano J, Gehrke L. RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling. MBio. 2016; 7(5). pii: e00833-16.
31. Naon D, Zaninello M, Giacomello M, Varanita T, Grespi F, Lakshminaranayan S, Serafini A, Semenzato M, Herkenne S, Hernández-Alvarez MI, Zorzano A, De Stefani D, Dorn GW, Scorrano L.  Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether.  PNAS. 2016; 113(40): 11249 ~ 11254.
32. Cohen-Kaplan V, Livneh I, Avni N, Fabre B, Ziv T, Kwon YT, Ciechanover A.  p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome.  PNAS. 2016;  113: E7490 ~ E7499.
33. Tian Y, Aursnes M, Hansen TV, Tungen JE, Galpin JD, Leisle L, Ahern CA, Xu R, Heinemann SH, Hoshi T. Atomic determinants of BK channel activation by polyunsaturated fatty acids.  PNAS. 2016; 113: 13905 ~ 13910.
34. Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E.  A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.  J Biol Chem. 2016; 291(45): 23569 ~ 23577.
35. Amin ND, Zheng Y, Bk B, Shukla V, Skuntz S, Grant P, Steiner J, Bhaskar M, Pant HC. The interaction of Munc 18 (p67) with the p10 domain of p35 protects in vivo Cdk5/p35 activity from inhibition by TFP5, a peptide derived from p35.  Mol Biol Cell. 2016; 27(21): 3221 ~ 3232.
36. Pennock S, Kim LA, Kazlauskas A.  Vascular Endothelial Cell Growth Factor A Acts via Platelet-Derived Growth Factor Receptor α To Promote Viability of Cells Enduring Hypoxia. Mol Cell Biol. 2016; 36(18): 2314 ~ 27.
37. Ajiro M, Tang S, Doorbar J, Zheng ZM.  Serine/Arginine-Rich Splicing Factor 3 and Heterogeneous Nuclear Ribonucleoprotein A1 Regulate Alternative RNA Splicing and Gene Expression of Human Papillomavirus 18 through Two Functionally Distinguishable cis Elements.  J Virol. 2016; 90(20): 9138 ~ 9152.
38. Yuan X, Rietzschel N, Kwon H, Walter Nuno AB, Hanna DA, Phillips JD, Raven EL, Reddi AR, Hamza I. Regulation of intracellular heme trafficking revealed by subcellular reporters. PNAS. 2016; 113(35): E5144 ~ 52.
39. Page KM, Rothwell SW, Dolphin AC. The CaVβ Subunit Protects the I-II Loop of the Voltage-gated Calcium Channel CaV2.2 from Proteasomal Degradation but Not Oligoubiquitination. J Biol Chem. 2016; 291 (39): 20402 ~ 16.
40. Shlevkov E, Kramer T, Schapansky J, LaVoie MJ, Schwarz TL. Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility. PNAS. 2016; 113: E6097 - E6106.
41. Lum R, Ahmad S, Hong SJ, Chapman DC, Kozlov G, Williams DB.  Contributions of the Lectin and Polypeptide Binding Sites of Calreticulin to Its Chaperone Functions in Vitro and in Cells.  J Biol Chem. 2016; 291(37): 19631 ~ 41.
42. Yao W, Oh YT, Deng J, Yue P, Deng L, Huang H, Zhou W, Sun SY. Expression of death receptor 4 is positively regulated by MEK/ERK/AP-1 signaling and suppressed upon MEK inhibition. J Biol Chem. 2016 291: 21694 ~ 21702.
43. Lin TV, Hsieh L, Kimura T, Malone TJ, Bordey A. Normalizing translation through 4E-BP prevents mTOR-driven cortical mislamination and ameliorates aberrant neuron integration. PNAS 2016; 113(40): 11330 ~ 11335.
44. Hahn AS, Großkopf AK, Jungnickl D, Scholz B, Ensser A. Viral FGARAT Homolog ORF75 of Rhesus Monkey Rhadinovirus Effects Proteasomal Degradation of the ND10 Components SP100 and PML. J Virol. 2016; 90(17): 8013 ~ 8328.
45. Shen W, Deng X, Zou W, Engelhardt JF, Yan Z, Qiu J. Analysis of cis and trans Requirements for DNA Replication at the Right-End Hairpin of the Human Bocavirus 1 Genome. J Virol. 2016; 90(17): 7761 ~ 7777.
46. Martin JL, Cao S, Maldonado JO, Zhang W, Mansky LM. Distinct Particle Morphologies Revealed through Comparative Parallel Analyses of Retrovirus-Like Particles. J Virol. 2016; 90(18): 8074 ~ 8084.
47. Sheehan P, Zhu M, Beskow A, Vollmer C, Waites CL. Activity-Dependent Degradation of Synaptic Vesicle Proteins Requires Rab35 and the ESCRT Pathway. J Neurosci. 2016; 36(33):8668 ~ 8686.
48. Fleet A, Lee JP, Tamachi A, Javeed I, Hamel PA. Activities of the Cytoplasmic Domains of Patched-1 Modulate but Are Not Essential for the Regulation of Canonical Hedgehog Signaling. J Biol Chem. 2016; 291(34): 17557 ~ 17568.
49. Curis C, Percher F, Jeannin P, Montange T, Chevalier SA, Seilhean D, Cartier L, Couraud PO, Gout O, Gessain A, Ceccaldi PE, Afonso PV. Human T-Lymphotropic Virus Type 1-Induced Overexpression of Activated Leukocyte Cell Adhesion Molecule (ALCAM) Facilitates Trafficking of Infected Lymphocytes through the Blood-Brain Barrier. J Virol. 2016; 90(16): 7303 ~ 7312.
50. Cornell B, Wachi T, Zhukarev V, Toyo-Oka K. Regulation of neuronal morphogenesis by 14-3-3epsilon (Ywhae) via the microtubule binding protein, doublecortin. Hum Mol Genet. 2016 Aug 9. pii: ddw270. [Epub ahead of print]
51. Rosin JM, Li W, Cox LL, Rolfe SM, Latorre V, Akiyama JA, Visel A, Kuramoto T, Bobola N, Turner EE, Cox TC. A distal 594bp ECR specifies Hmx1 expression in pinna and lateral facial morphogenesis and is regulated by Hox-Pbx-Meis. Development. 2016; 143: 2582 ~ 2592.
52. Zhao Y, Tang JW, Yang Z, Cao YB, Ren JL, Ben-Abu Y, Li K, Chen XQ, Du JZ and Nevo E.  Adaptive methylation regulation of p53 pathway in sympatric speciation of blind mole rats, Spalax. PNAS, 2016; 113: 2146 ~ 2151.
53. Zhao DY, Gish G, Braunschweig U, Li Y, Ni Z, Schmitges FW, Zhong G, Liu K, Li W, Moffat J, Vedadi M, Min J, Pawson TJ, Blencowe BJ, Greenblatt JF. SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination. Nature. 2016; 529 (7584): 48 ~ 53.
54. Acharya S, Xu J, Wang X, Jain S, Wang H, Zhang Q, Chang CC, Bower J, Arun B, Seewaldt V, Yu D. Downregulation of GLUT4 contributes to effective intervention of estrogen receptor-negative/HER2-overexpressing early stage breast disease progression by lapatinib. Am J Cancer Res. 2016; 6(5): 981 ~ 95.
55. Hatakeyama J, Wald JH, Rafidi H, Cuevas A, Sweeney C, Carraway KL. The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3. Sci Signal. 2016; 9: ra65.
56. Kunze MM, Benz F, Brauß TF, Lampe S, Weigand JE, Braun J, Richter FM, Wittig I, Brüne B, Schmid T. sST2 translation is regulated by FGF2 via an hnRNP A1-mediated IRES-dependent mechanism. Biochim Biophys Acta. 2016; 1859(7): 848 ~ 59.
57. Qi HL1, Li CS2, Qian CW2, Xiao YS2, Yuan YF2, Liu QY2, Liu ZS2.  The long noncoding RNA, EGFR-AS1, a target of GHR, increases the expression of EGFR in hepatocellular carcinoma.  Tumour Biol. 2016; 37(1): 1079 ~ 89.
58. Chen KD, Huang KT, Lin CC, Weng WT, Hsu LW, Goto S, Nakano T, Lai CY, Kung CP, Chiu KW, Wang CC, Cheng YF, Ma YY, Chen CL. MicroRNA-27b Enhances the Hepatic Regenerative Properties of Adipose-Derived Mesenchymal Stem Cells.  Mol Ther Nucleic Acids. 2016; 5:e285.
59. Salloum-Asfar S, Arroyo AB, Teruel-Montoya R, García-Barberá N, Roldán V, Vicente V, Martínez C, González-Conejero R.  MiRNA-Based Regulation of Hemostatic Factors through Hepatic Nuclear Factor-4 Alpha.  PLoS One.2016; 11(5): e0154751.
60. Liu Z, Ma C, Shen J, Wang D, Hao J, Hu Z.  SDF‑1/CXCR4 axis induces apoptosis of human degenerative nucleus pulposus cells via the NF‑κB pathway.  Mol Med Rep. 2016 May 24. doi: 10.3892/mmr.2016.5341. [Epub ahead of print]
61. Xi G, Shen X, Rosen CJ, Clemmons DR.  IRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation.  J Bone Miner Res. 2016; 31(6): 1300 ~ 14.
62. Chauvin L, Goupille C, Blanc C, Pinault M, Domingo I, Guimaraes C, Bougnoux P, Chevalier S, Mahéo K. Long chain n-3 polyunsaturated fatty acids increase the efficacy of docetaxel in mammary cancer cells by downregulating Akt and PKCε/δ-induced ERK pathways. Biochim Biophys Acta. 2016; 1861(4): 380 ~ 90.
63. Rowson-Hodel AR, Berg AL, Wald JH, Hatakeyama J, VanderVorst K, Curiel DA, Leon LJ, Sweeney C, Carraway KL. Hexamethylene amiloride engages a novel reactive oxygen species- and lysosome-dependent programmed necrotic mechanism to selectively target breast cancer cells. Cancer Lett. 2016; 375(1): 62 ~ 72.
64. An R, Wang Y, Voeller D, Gower A, Kim IK, Zhang YW, Giaccone G.  CRKL mediates EML4-ALK signaling and is a potential therapeutic target for ALK-rearranged lung adenocarcinoma. Oncotarget. 2016 Apr 7. doi: 10.18632/oncotarget.8638. [Epub ahead of print]
65. Luengo-Gil G, Calvo MI, Martín-Villar E, Águila S, Bohdan N, Antón AI, Espín S, Ayala de la Peña F1, Vicente V1, Corral J1, Quintanilla M2, Martínez-Martínez I1. Antithrombin controls tumor migration, invasion and angiogenesis by inhibition of enteropeptidase. Sci Rep. 2016; 6: 27544.
66. Chang CC, Zhang C, Zhang Q, Sahin O, Wang H, Xu J, Xiao Y, Zhang J, Rehman SK, Li P, Hung MC, Behbod F, Yu D. Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression. Oncotarget. 2016 May 2. doi: 10.18632/oncotarget.9136. [Epub ahead of print]
67. Williams A, Hayashi T, Wolozny D, Yin B, Su TC, Betenbaugh MJ, Su TP. The non-apoptotic action of Bcl-xL: regulating Ca(2+) signaling and bioenergetics at the ER-mitochondrion interface. J Bioenerg Biomembr. 2016; 48(3): 211 ~ 25.
68. Astudillo L, Da Silva TG, Wang Z, Han X, Jin K, VanWye J, Zhu X, Weaver K, Oashi T, Lopes PE, Orton D, Neitzel LR, Lee E, Landgraf R, Robbins DJ, MacKerell AD Jr, Capobianco AJ.  The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016; 76: 3593 ~ 3603.
69. Boden J, Lassance-Soares RM, Wang H, Wei Y, Spiga MG, Adi J, Layman H, Yu H, Vazquez-Padron RI, Andreopoulos F, Webster KA. ​Vascular Regeneration in Ischemic Hindlimb by Adeno-Associated Virus Expressing Conditionally Silenced Vascular Endothelial Growth Factor. J Am Heart Assoc. 2016; 5(6). pii: e001815.
70. Lutz LM, Pace CR, Arnold MM.  Rotavirus NSP1 associates with components of the cullin RING ligase family of E3 ubiquitin ligases.  J Virol. 2016; 90: 6036 ~ 6048.
71. von Bredow B, Arias JF, Heyer LN, Moldt B, Le K, Robinson JE, Zolla-Pazner S, Burton DR, Evans DT.  Comparison of Antibody-Dependent Cell-Mediated Cytotoxicity and Virus Neutralization by HIV-1 Env-specific Monoclonal Antibodies.  J Virol. 2016; 90: 6127 ~ 6139.
72. Vlčková K, Ondrušová L, Vachtenheim J, Réda J, Dundr P, Zadinová M, Žáková P, Poučková P. Survivin, a novel target of the Hedgehog/GLI signaling pathway in human tumor cells. Sci Rep. 2016; 6: 23206. 
73. Ma X, Jiao X, Ma Z, Hejtmancik JF. Polymorphism rs7278468 is associated with Age-related cataract through decreasing transcriptional activity of the CRYAA promoter. Cell Death Dis. 2016; 7: e2048.
74. Sztukowska MN, Ojo A, Ahmed S, Carenbauer AL, Wang Q, Shumway B, Jenkinson HF, Wang H, Darling DS, Lamont RJ. Porphyromonas gingivalis initiates a mesenchymal-like transition through ZEB1 in gingival epithelial cells. Cell Microbiol. 2016; 18(6): 844 ~ 58.
75. Bullen JW, Tchernyshyov I, Holewinski RJ, DeVine L, Wu F, Venkatraman V, Kass DL, Cole RN, Eyk JV and Semenza GL. Protein kinase A–dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1. Sci. Signal., 2016; 9: ra56.
76. Li S, Samardzija M, Yang Z, Grimm C and Jin M. Pharmacological Amelioration of Cone Survival and Vision in a Mouse Model for Leber Congenital Amaurosis. J. Neurosci., 2016; 36: 5808 ~ 5819.
77. Allodi I, Comley L, Nichterwitz S, Nizzardo M, Simone C, Benitez JA, Cao M, Corti S, Hedlund E.  Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS. Sci Rep. 2016; 6: 25960.
78. McGarvey JC, Xiao K, Bowman SL, Mamonova T, Zhang Q, Bisello A, Sneddon WB, Ardura JA, Jean-Alphonse F, Vilardaga JP, Puthenveedu MA, Friedman PA. Actin-Sorting Nexin 27-Retromer Complex Mediates Rapid Parathyroid Hormone Receptor Recycling.  J Biol Chem. 2016;  291: 10986 ~ 11002.
79. Tartaglia LJ, Chang HW, Lee BC, Abbink P, Nganga D, Boyd M, Lavine CL, Lim SY, Sanisetty S, Whitney JB, Seaman MS, Rolland M, Tovanabutra S, Ananworanich J, Robb ML, Kim JH, Michael NL, Barouch DH.  Production of Mucosally Transmissible SHIV Challenge Stocks from HIV-1 Circulating Recombinant Form 01_AE env Sequences.  PLoS Pathog. 2016; 12(2):e1005431.
80. Rahme GJ, Zhang Z, Young AL, Cheng C, Bivona EJ, Fiering SN, Hitoshi Y, Israel MA.  PDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-mediated Survival of Proneural Glioma Cells. Cancer Res. 2016; 76: 2964 - 2976.
81. Weyemi U, Redon CE, Choudhuri R, Aziz T, Maeda D, Boufraqech M, Parekh PR, Sethi TK, Kasoji M, Abrams N, Merchant A, Rajapakse VN, Bonner WM. The histone variant H2A.X is a regulator of the epithelial-mesenchymal transition. Nat Commun. 2016; 7: 10711.
82. Chaly AL, Srisai D, Gardner EE, Sebag JA.  The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1. Elife. 2016; 5. pii: e12397.
83. Domènech-Estévez EC, Baloui H, Meng X, Zhang Y, Deinhardt K, Dupree JL, Einheber S, Chrast R and Salzer JL. Akt Regulates Axon Wrapping and Myelin Sheath Thickness in the PNS. J. Neurosci., Apr 2016; 36: 4506 - 4521.
84. Zheng D, Yu Y, Li M, Wang G, Chen R, Fan GC, Martin C, Xiong S, Peng T.  Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis. J Infect Dis. 2016; 213: 1661 ~ 1670.
85. Chatterjee G, Jimenez-Sainz J, Presti T, Nguyen T, Jensen RB.  Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity.  Nucleic Acids Res. 2016; 44: 5256 ~ 5270.
86. Su CI, Tseng CH, Yu CY, Lai MM. SUMO Modification Stabilizes Dengue Virus Nonstructural Protein 5. J Virol. 2016; 90: 4308 ~ 4319.
87. Zou W, Cheng F, Shen W, Engelhardt JF, Yan Z, Qiu J. Nonstructural Protein NP1 of Human Bocavirus 1 Plays a Critical Role in the Expression of Viral Capsid Proteins. J Virol. 2016; 90: 4658 ~ 4669.
88. Siu GK, Zhou F, Yu MK, Zhang L, Wang T, Liang Y, Chen Y, Chan HC and Yu S.  Hepatitis C virus NS5A protein cooperates with phosphatidylinositol 4-kinase IIIα to induce mitochondrial fragmentation.  Sci Rep. 2016; 6: 23464.
89. Xu DQ, Wang Z, Wang CY, Zhang DY, Wan HD, Zhao ZL, Gu J, Zhang YX, Li ZG, Man KY, Pan Y, Wang ZF, Ke ZJ, Liu ZX, Liao LJ, Chen Y. PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity. EMBO J. 2016; 35(5):496 ~ 514.
90. Nassour J, Martien S, Martin N, Deruy E, Tomellini E, Malaquin N, Bouali F, Sabatier L, Wernert N, Pinte S, Gilson E, Pourtier A, Pluquet O, Abbadie C.  Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells.  Nat Commun. 2016; 7: 10399.
91. Wen B, Li S, Li H, Chen Y, Ma X, Wang J, Lu F, Qu J, Hou L.  Microphthalmia-associated transcription factor regulates the visual cycle genes Rlbp1 and Rdh5 in the retinal pigment epithelium.  Sci Rep. 2016; 6: 21208.
92. Ahlskog JK, Larsen BD, Achanta K and Sørensen CS.  ATM/ATR-mediated phosphorylation of PALB2 promotes RAD51 function.  EMBO Rep., 2016; 10.15252/embr.201541455.
93. Tang X, Zhao YY, Dewald J, Curtis JM, Brindley DN. Tetracyclines increase the expression of lipid phosphate phosphatases on plasma membranes and the turnover of plasma lysophosphatidate. J Lipid Res. 2016; 57: 597 - 606.
94. Hoffmann HM, Trang C, Gong P, Kimura I, Pandolfi EC and Mellon PL. Deletion of Vax1 from Gonadotropin-Releasing Hormone (GnRH) Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility.  J. Neurosci., 2016; 36: 3506 ~ 3518.
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96. Shin HR, Islam R, Yoon WJ, Lee T, Cho YD, Bae HS, Kim BS, Woo KM, Baek JH, Ryoo HM.  Pin1-mediated modification prolongs the nuclear retention of β-catenin in Wnt3a-induced osteoblast differentiation.  J Biol Chem. 2016; 291: 5555 ~ 5565.
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