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Interferonswereoriginallydiscoveredasantiviralfactors,butlaterstudiesshowedtheyaresecretedinresponsetomanydifferentpathogens,includingbacteriaandfungi.
TypeIIFNsareresponsibleforinducingtranscriptionofalargegroupofgeneswhichplayaroleinhostresistancetoviralinfections,aswellasactivatingkeycomponentsoftheinnateandadaptiveimmunesystemsincludingantigenpresentationandproductionofcytokinesinvolvedinactivationofTcells,Bcells,andnaturalkillercells.
TypeIInterferons(IFNs)activateintercellurantimicrobialsignalingcascadesandhaveaneffectonthedevelopmentofinnateandadaptiveimmuneresponses.
CanonicaltypeIIFNsignalingactivatesthejanuskinase(JAK)-signaltransducerandactivatoroftranscription(STAT)pathway,leadingtotranscriptionofIFN-stimulatedgenes(ISGs).
Pathogen,hostandenvironmentalfactorsregulatetheresponsesofcellstothissignalingpathwayandthereforecalibratehostdefencesaswellaslimitingtissuedamageandpreventingautoimmunity.
Name | Reactswith | Applications | CatalogNumber |
gammaIFN | Mouse | ELISA,WB,IHC-P,IF/ICC,IP | orb22685 |
Il1beta | Human,Mouse,Rat | WB,IHC-P,P-ELISA | orb10903 |
IFNGR1 | Human,Mouse,Rat,Monkey | WB | orb214083 |
Il12 | Mouse,Rat,GuineaPig | P-ELISA | orb10893 |
STAT6 | Human | WB,IHC-P | orb14463 |
IRF1 | Human | WB,IHC-P | orb154601 |
IRF2 | Human,Mouse,Rat | WB,IHC-P,P-ELISA | orb128228 |
IRF3 | Human,Mouse,Rat,Cow,Dog,Horse,Pig | WB,IHC-P,P-ELISA | orb6224 |
C2 | Human | WB,IHC-P,FACS | orb39265 |
TNF-alpha | Human,Mouse,Rat,Pig | IHC-P,IF/ICC | orb221324 |
HMG1 | Human | ELISA,WB,IHC-P,IF/ICC | orb89610 |