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Signalchem/IRAK4 siRNA Set I/50 nmol/I12-911-50

Overview:

Interleukin-1receptor-associatedkinase4(IRAK4)isanimportantmediatorinthesignaltransductionofToll-likereceptor(TLR)andIL1Rfamilymembers(1).IRAK4isinvolvedintheToll-likereceptorsignalingpathwayleADIngtoApoptosis.IRAK4hasmolecularfunctionslikeproteinbinding,ATPbinding,kinaseactivityandmagnesiumionbinding.Toll/IL-1receptorfamilymemberslikeIRAK4arecentralcomponentsofhostdefensemechanismsinavarietyofspecies(2).OnewellconservedelementintheirsignaltransductionistheSer/Thrkinaseactivitywhichcoupleearlysignalingeventsinareceptorcomplexattheplasmamembranetolargersignalosomesinthecytosol.

GeneAliases:

IPD1,REN64,NY-REN-64

GenbankNumber:

BC013316

References:

1.Li,S.etal:IRAK-4:anovelmemberoftheIRAKfamilywiththepropertiesofanIRAK-kinase.Proc.Natl.Acad.Sci.USA.2002;99:5567-72.2.Suzuki,N.etal:IRAK-4asthecentralTIRsignalingmediatorininnateimmunity.TrendsImmunol.2002;23:503-6.

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