Overview:
Interleukin-1receptor-associatedkinase4(IRAK4)isanimportantmediatorinthesignaltransductionofToll-likereceptor(TLR)andIL1Rfamilymembers(1).IRAK4isinvolvedintheToll-likereceptorsignalingpathwayleADIngtoApoptosis.IRAK4hasmolecularfunctionslikeproteinbinding,ATPbinding,kinaseactivityandmagnesiumionbinding.Toll/IL-1receptorfamilymemberslikeIRAK4arecentralcomponentsofhostdefensemechanismsinavarietyofspecies(2).OnewellconservedelementintheirsignaltransductionistheSer/Thrkinaseactivitywhichcoupleearlysignalingeventsinareceptorcomplexattheplasmamembranetolargersignalosomesinthecytosol.
GeneAliases:
IPD1,REN64,NY-REN-64
GenbankNumber:
BC013316
References:
1.Li,S.etal:IRAK-4:anovelmemberoftheIRAKfamilywiththepropertiesofanIRAK-kinase.Proc.Natl.Acad.Sci.USA.2002;99:5567-72.2.Suzuki,N.etal:IRAK-4asthecentralTIRsignalingmediatorininnateimmunity.TrendsImmunol.2002;23:503-6.
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goprolytix/Proteolytic Activation of Prothrombin/1 mg, 200 µg/BCT-DFP
novateinbio/Dynorphin A ( 13-17 ) Porcine Peptide/5mg/PE-54024_5mg
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